Detailed information NTG0864471

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: Q7619_RS11070
• Genome accession: NZ_CP131714
• Coordinates: 2140982..2141734 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 2008C04-309
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2135982..2146734

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7619_RS11050 (Q7619_11015)	-	2138415..2140018 (-)	1604	Protein_2138	YhgE/Pip domain-containing protein	-
Q7619_RS11055 (Q7619_11020)	-	2140197..2140739 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
Q7619_RS11070 (Q7619_11035)	comE	2140982..2141734 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
Q7619_RS11075 (Q7619_11040)	comD/comD1	2141731..2143056 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
Q7619_RS11080 (Q7619_11045)	comC/comC1	2143077..2143202 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
Q7619_RS11090 (Q7619_11055)	rlmH	2143484..2143963 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
Q7619_RS11095 (Q7619_11060)	htrA	2144146..2145327 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
Q7619_RS11100 (Q7619_11065)	spo0J	2145385..2146143 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=864471 Q7619_RS11070 WP_000866065.1 2140982..2141734(-) (comE) [Streptococcus pneumoniae strain 2008C04-309]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=864471 Q7619_RS11070 WP_000866065.1 2140982..2141734(-) (comE) [Streptococcus pneumoniae strain 2008C04-309]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAAGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408