Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   Q7619_RS09480 Genome accession   NZ_CP131714
Coordinates   1832662..1833918 (-) Length   418 a.a.
NCBI ID   WP_000642705.1    Uniprot ID   A0A0T7I3F9
Organism   Streptococcus pneumoniae strain 2008C04-309     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1817928..1847753 1832662..1833918 within 0


Gene organization within MGE regions


Location: 1817928..1847753
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7619_RS09420 (Q7619_09390) - 1817928..1818327 (+) 400 Protein_1843 transposase family protein -
  Q7619_RS09425 (Q7619_09395) - 1818821..1819681 (+) 861 WP_001810270.1 glycerophosphodiester phosphodiesterase family protein -
  Q7619_RS09430 (Q7619_09400) - 1819665..1820726 (+) 1062 WP_000475761.1 extracellular solute-binding protein -
  Q7619_RS09435 (Q7619_09405) - 1820743..1821747 (+) 1005 WP_000627599.1 ABC transporter ATP-binding protein -
  Q7619_RS09440 (Q7619_09410) - 1821759..1823453 (+) 1695 WP_001232286.1 iron ABC transporter permease -
  Q7619_RS09445 (Q7619_09415) - 1823455..1824156 (+) 702 WP_001054457.1 MgtC/SapB family protein -
  Q7619_RS09450 (Q7619_09420) - 1824203..1824802 (+) 600 WP_001021235.1 HAD family phosphatase -
  Q7619_RS09455 (Q7619_09425) - 1824812..1826839 (+) 2028 WP_000256298.1 extracellular solute-binding protein -
  Q7619_RS09460 (Q7619_09430) - 1826998..1827799 (+) 802 Protein_1851 IS5 family transposase -
  Q7619_RS09465 (Q7619_09435) lytA 1828432..1829388 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  Q7619_RS09470 (Q7619_09440) - 1829764..1831134 (-) 1371 WP_341948123.1 MATE family efflux transporter -
  Q7619_RS09475 (Q7619_09445) recA 1831441..1832607 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  Q7619_RS09480 (Q7619_09450) cinA 1832662..1833918 (-) 1257 WP_000642705.1 competence/damage-inducible protein A Machinery gene
  Q7619_RS09485 (Q7619_09455) - 1834003..1835019 (-) 1017 WP_000239278.1 LCP family protein -
  Q7619_RS09490 (Q7619_09460) - 1835027..1835545 (-) 519 WP_000455534.1 GNAT family N-acetyltransferase -
  Q7619_RS09495 (Q7619_09465) tsaE 1835535..1835978 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  Q7619_RS09500 (Q7619_09470) comM 1836064..1836684 (-) 621 WP_000839905.1 hypothetical protein Regulator
  Q7619_RS09505 (Q7619_09475) - 1837067..1837930 (-) 864 WP_001093619.1 helix-turn-helix transcriptional regulator -
  Q7619_RS09510 (Q7619_09480) - 1838122..1838292 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  Q7619_RS09515 (Q7619_09485) pneA1 1838395..1838619 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  Q7619_RS09520 (Q7619_09490) pneA2 1838626..1838814 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  Q7619_RS09525 (Q7619_09495) lanM 1838931..1841921 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM -
  Q7619_RS09530 (Q7619_09500) - 1842271..1842975 (+) 705 WP_001033170.1 flavodoxin family protein -
  Q7619_RS09535 (Q7619_09505) - 1842956..1843885 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  Q7619_RS09540 (Q7619_09510) - 1843882..1845990 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  Q7619_RS09545 (Q7619_09515) - 1846014..1847753 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45047.43 Da        Isoelectric Point: 4.6064

>NTDB_id=864448 Q7619_RS09480 WP_000642705.1 1832662..1833918(-) (cinA) [Streptococcus pneumoniae strain 2008C04-309]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGASSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=864448 Q7619_RS09480 WP_000642705.1 1832662..1833918(-) (cinA) [Streptococcus pneumoniae strain 2008C04-309]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTAACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGCTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACCGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CATATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T7I3F9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae Rx1

99.043

100

0.99
  cinA Streptococcus pneumoniae R6

99.043

100

0.99
  cinA Streptococcus pneumoniae D39

98.804

100

0.988
  cinA Streptococcus mitis SK321

94.258

100

0.943
  cinA Streptococcus mitis NCTC 12261

94.019

100

0.94
  cinA Streptococcus mutans UA159

71.292

100

0.713
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.694

100

0.457