Detailed information NTG0864236

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: Q7622_RS10700
• Genome accession: NZ_CP131711
• Coordinates: 2087733..2088485 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 2014C08-275
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2082733..2093485

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7622_RS10675 (Q7622_10630)	-	2083112..2085664 (+)	2553	WP_000834680.1	YfhO family protein	-
Q7622_RS10680 (Q7622_10635)	-	2085694..2086841 (-)	1148	Protein_2065	YhgE/Pip family protein	-
Q7622_RS10685 (Q7622_10640)	-	2086948..2087490 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
Q7622_RS10700 (Q7622_10655)	comE	2087733..2088485 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
Q7622_RS10705 (Q7622_10660)	comD/comD1	2088482..2089807 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
Q7622_RS10710 (Q7622_10665)	comC/comC1	2089828..2089953 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
Q7622_RS10720 (Q7622_10675)	rlmH	2090235..2090714 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
Q7622_RS10725 (Q7622_10680)	htrA	2090897..2092078 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
Q7622_RS10730 (Q7622_10685)	spo0J	2092136..2092894 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=864236 Q7622_RS10700 WP_000866065.1 2087733..2088485(-) (comE) [Streptococcus pneumoniae strain 2014C08-275]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=864236 Q7622_RS10700 WP_000866065.1 2087733..2088485(-) (comE) [Streptococcus pneumoniae strain 2014C08-275]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408