Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   Q7625_RS09445 Genome accession   NZ_CP131708
Coordinates   1853425..1854681 (-) Length   418 a.a.
NCBI ID   WP_000642705.1    Uniprot ID   A0A0T7I3F9
Organism   Streptococcus pneumoniae strain 2016C10-332     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1846321..1868515 1853425..1854681 within 0


Gene organization within MGE regions


Location: 1846321..1868515
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7625_RS09405 (Q7625_09390) - 1846321..1847115 (-) 795 WP_001101205.1 hypothetical protein -
  Q7625_RS09410 (Q7625_09395) - 1847523..1847948 (-) 426 WP_000204064.1 hypothetical protein -
  Q7625_RS09415 (Q7625_09400) - 1848077..1848436 (-) 360 WP_001814321.1 hypothetical protein -
  Q7625_RS09420 (Q7625_09405) - 1848482..1848688 (-) 207 WP_000366093.1 hypothetical protein -
  Q7625_RS09425 (Q7625_09410) - 1848675..1848836 (-) 162 WP_000289348.1 helix-turn-helix transcriptional regulator -
  Q7625_RS09430 (Q7625_09415) lytA 1849195..1850151 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  Q7625_RS09435 (Q7625_09420) - 1850527..1851897 (-) 1371 WP_341922451.1 MATE family efflux transporter -
  Q7625_RS09440 (Q7625_09425) recA 1852204..1853370 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  Q7625_RS09445 (Q7625_09430) cinA 1853425..1854681 (-) 1257 WP_000642705.1 competence/damage-inducible protein A Machinery gene
  Q7625_RS09450 (Q7625_09435) - 1854766..1855782 (-) 1017 WP_000239284.1 LCP family protein -
  Q7625_RS09455 (Q7625_09440) - 1855790..1856308 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  Q7625_RS09460 (Q7625_09445) tsaE 1856298..1856741 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  Q7625_RS09465 (Q7625_09450) comM 1856827..1857447 (-) 621 WP_000839908.1 hypothetical protein Regulator
  Q7625_RS09470 (Q7625_09455) - 1857830..1858693 (-) 864 WP_001093641.1 helix-turn-helix transcriptional regulator -
  Q7625_RS09475 (Q7625_09460) - 1858885..1859055 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  Q7625_RS09480 (Q7625_09465) pneA1 1859158..1859382 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  Q7625_RS09485 (Q7625_09470) pneA2 1859389..1859577 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  Q7625_RS09490 (Q7625_09475) lanM 1859693..1862683 (+) 2991 WP_000875569.1 type 2 lanthipeptide synthetase LanM -
  Q7625_RS09495 (Q7625_09480) - 1863033..1863737 (+) 705 WP_001033170.1 flavodoxin family protein -
  Q7625_RS09500 (Q7625_09485) - 1863718..1864647 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  Q7625_RS09505 (Q7625_09490) - 1864644..1866752 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  Q7625_RS09510 (Q7625_09495) - 1866776..1868515 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45047.43 Da        Isoelectric Point: 4.6064

>NTDB_id=863983 Q7625_RS09445 WP_000642705.1 1853425..1854681(-) (cinA) [Streptococcus pneumoniae strain 2016C10-332]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGASSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=863983 Q7625_RS09445 WP_000642705.1 1853425..1854681(-) (cinA) [Streptococcus pneumoniae strain 2016C10-332]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTAACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGCTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACCGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CATATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T7I3F9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae Rx1

99.043

100

0.99
  cinA Streptococcus pneumoniae R6

99.043

100

0.99
  cinA Streptococcus pneumoniae D39

98.804

100

0.988
  cinA Streptococcus mitis SK321

94.258

100

0.943
  cinA Streptococcus mitis NCTC 12261

94.019

100

0.94
  cinA Streptococcus mutans UA159

71.292

100

0.713
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.694

100

0.457