Detailed information NTG0850752

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: LBA42_RS07065
• Genome accession: NZ_CP145437
• Coordinates: 1394753..1395505 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: Q79CK7
• Organism: Streptococcus pneumoniae strain HAC 39-1996
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1389753..1400505

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LBA42_RS07035 (LBA42_07035)	spo0J	1390344..1391102 (-)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator
LBA42_RS07040 (LBA42_07040)	htrA	1391160..1392341 (-)	1182	WP_000681598.1	S1C family serine protease	Regulator
LBA42_RS07045 (LBA42_07045)	rlmH	1392524..1393003 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
LBA42_RS07055 (LBA42_07055)	comC/comC1	1393285..1393410 (+)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
LBA42_RS07060 (LBA42_07060)	comD/comD1	1393431..1394756 (+)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
LBA42_RS07065 (LBA42_07065)	comE	1394753..1395505 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
LBA42_RS07080 (LBA42_07080)	-	1395748..1396290 (-)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
LBA42_RS07085 (LBA42_07085)	-	1396469..1398072 (+)	1604	Protein_1398	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=850752 LBA42_RS07065 WP_000866065.1 1394753..1395505(+) (comE) [Streptococcus pneumoniae strain HAC 39-1996]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=850752 LBA42_RS07065 WP_000866065.1 1394753..1395505(+) (comE) [Streptococcus pneumoniae strain HAC 39-1996]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAAGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• PDB: 4CBV

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408