Detailed information NTG0809332

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLHP_RS04400
• Genome accession: NZ_CP120921
• Coordinates: 865652..866344 (+)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris subsp. cremoris HP
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 860652..871344

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLHP_RS04370 (LLHP_04390)	-	860818..861654 (+)	837	WP_032950298.1	metallophosphoesterase	-
LLHP_RS04375 (LLHP_04395)	-	861800..862648 (+)	849	WP_231099822.1	CHAP domain-containing protein	-
LLHP_RS04380 (LLHP_04400)	-	862885..863247 (+)	363	Protein_852	TIGR02328 family protein	-
LLHP_RS04385 (LLHP_04405)	-	863571..863816 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLHP_RS04390 (LLHP_04410)	-	863921..864811 (-)	891	WP_396424831.1	IS982 family transposase	-
LLHP_RS04395 (LLHP_04415)	-	864965..865495 (+)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLHP_RS04400 (LLHP_04420)	covR	865652..866344 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLHP_RS04405 (LLHP_04425)	covS	866357..867829 (+)	1473	WP_032950293.1	HAMP domain-containing histidine kinase	Regulator
LLHP_RS04410 (LLHP_04430)	-	868015..869256 (+)	1242	WP_015082643.1	ammonium transporter	-
LLHP_RS04415 (LLHP_04435)	-	869340..869681 (+)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLHP_RS04420 (LLHP_04440)	murD	869850..871199 (+)	1350	WP_032950291.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=809332 LLHP_RS04400 WP_011676631.1 865652..866344(+) (covR) [Lactococcus cremoris subsp. cremoris HP]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=809332 LLHP_RS04400 WP_011676631.1 865652..866344(+) (covR) [Lactococcus cremoris subsp. cremoris HP]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361