Detailed information NTG0795651

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: PYH54_RS09620
• Genome accession: NZ_CP118830
• Coordinates: 1963395..1964438 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 7054
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1958395..1969438

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PYH54_RS09590 (PYH54_09595)	-	1958817..1960073 (-)	1257	WP_001793428.1	aminopeptidase	-
PYH54_RS09595 (PYH54_09600)	-	1960076..1960276 (-)	201	WP_000180460.1	DUF1128 family protein	-
PYH54_RS09600 (PYH54_09605)	-	1960423..1960887 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
PYH54_RS09605 (PYH54_09610)	-	1960894..1961169 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
PYH54_RS09610 (PYH54_09615)	-	1961447..1962664 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
PYH54_RS09615 (PYH54_09620)	vraR	1962776..1963405 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
PYH54_RS09620 (PYH54_09625)	vraS	1963395..1964438 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
PYH54_RS09625 (PYH54_09630)	liaF	1964435..1965136 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
PYH54_RS09630 (PYH54_09635)	-	1965151..1965537 (-)	387	WP_001110179.1	hypothetical protein	-
PYH54_RS09635 (PYH54_09640)	map	1965754..1966512 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
PYH54_RS09640 (PYH54_09645)	-	1967043..1968029 (+)	987	WP_000999716.1	aromatic acid exporter family protein	-
PYH54_RS09645 (PYH54_09650)	-	1968519..1968932 (-)	414	WP_001670387.1	hypothetical protein	-
PYH54_RS09650 (PYH54_09655)	-	1968961..1969071 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=795651 PYH54_RS09620 WP_001017131.1 1963395..1964438(-) (vraS) [Staphylococcus aureus strain 7054]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=795651 PYH54_RS09620 WP_001017131.1 1963395..1964438(-) (vraS) [Staphylococcus aureus strain 7054]
ATGAACCATTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1