Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   PVK49_RS08610 Genome accession   NZ_CP118306
Coordinates   1741409..1742680 (-) Length   423 a.a.
NCBI ID   WP_047236047.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 20154608     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1736409..1747680
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PVK49_RS08585 (PVK49_08570) - 1738379..1738684 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  PVK49_RS08590 (PVK49_08575) ruvX 1738696..1739115 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  PVK49_RS08595 (PVK49_08580) - 1739112..1739381 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  PVK49_RS08600 (PVK49_08585) spx 1739495..1739893 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  PVK49_RS08605 (PVK49_08590) recA 1740184..1741320 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  PVK49_RS08610 (PVK49_08595) cinA 1741409..1742680 (-) 1272 WP_047236047.1 competence/damage-inducible protein A Machinery gene
  PVK49_RS08615 (PVK49_08600) - 1742749..1743309 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  PVK49_RS08620 (PVK49_08605) ruvA 1743319..1743915 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  PVK49_RS08625 (PVK49_08610) - 1743917..1745137 (-) 1221 WP_047236048.1 MFS transporter -
  PVK49_RS08630 (PVK49_08615) mutL 1745148..1747130 (-) 1983 WP_047236089.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45970.69 Da        Isoelectric Point: 4.8322

>NTDB_id=791494 PVK49_RS08610 WP_047236047.1 1741409..1742680(-) (cinA) [Streptococcus pyogenes strain 20154608]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=791494 PVK49_RS08610 WP_047236047.1 1741409..1742680(-) (cinA) [Streptococcus pyogenes strain 20154608]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATA
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461