Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYC   Type   Machinery gene
Locus tag   MGCS35957_RS00730 Genome accession   NZ_CP117288
Coordinates   122864..123190 (+) Length   108 a.a.
NCBI ID   WP_084916953.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 88254..121895 122864..123190 flank 969


Gene organization within MGE regions


Location: 88254..123190
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGCS35957_RS00585 (MGCS35957_00240) - 88254..89387 (-) 1134 WP_001007677.1 site-specific integrase -
  MGCS35957_RS00590 (MGCS35957_00242) - 89392..89586 (-) 195 WP_000562208.1 DUF3173 family protein -
  MGCS35957_RS00595 (MGCS35957_00244) - 89655..91001 (-) 1347 WP_084916941.1 Rep family protein -
  MGCS35957_RS00600 (MGCS35957_00246) - 91352..91711 (-) 360 WP_025194534.1 hypothetical protein -
  MGCS35957_RS00605 (MGCS35957_00248) - 91726..92064 (-) 339 WP_000092752.1 hypothetical protein -
  MGCS35957_RS00610 (MGCS35957_00250) - 92314..92769 (+) 456 WP_000021848.1 helix-turn-helix domain-containing protein -
  MGCS35957_RS00615 (MGCS35957_00252) - 93067..94196 (+) 1130 Protein_85 IS3 family transposase -
  MGCS35957_RS00620 (MGCS35957_00254) - 94284..94616 (-) 333 WP_000181338.1 hypothetical protein -
  MGCS35957_RS00625 (MGCS35957_00256) - 94627..95034 (-) 408 WP_000351058.1 helix-turn-helix transcriptional regulator -
  MGCS35957_RS00630 - 95290..95604 (+) 315 Protein_88 transposase -
  MGCS35957_RS00635 (MGCS35957_00260) - 96024..96560 (+) 537 WP_041788713.1 NUDIX domain-containing protein -
  MGCS35957_RS00640 (MGCS35957_00262) - 96695..97594 (+) 900 WP_003058398.1 prenyltransferase -
  MGCS35957_RS00645 (MGCS35957_00264) - 97609..98817 (+) 1209 WP_065358554.1 NAD(P)/FAD-dependent oxidoreductase -
  MGCS35957_RS00650 (MGCS35957_00266) - 98927..100354 (+) 1428 WP_084916943.1 cytochrome ubiquinol oxidase subunit I -
  MGCS35957_RS00655 (MGCS35957_00268) cydB 100355..101374 (+) 1020 WP_084916945.1 cytochrome d ubiquinol oxidase subunit II -
  MGCS35957_RS00660 (MGCS35957_00270) cydD 101374..103089 (+) 1716 WP_003055281.1 thiol reductant ABC exporter subunit CydD -
  MGCS35957_RS00665 (MGCS35957_00272) cydC 103086..104834 (+) 1749 WP_065355135.1 thiol reductant ABC exporter subunit CydC -
  MGCS35957_RS00670 (MGCS35957_00274) - 104899..105879 (-) 981 WP_084916947.1 polyprenyl synthetase family protein -
  MGCS35957_RS00675 (MGCS35957_00276) ispE 106135..106986 (+) 852 WP_003061506.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
  MGCS35957_RS00680 (MGCS35957_00278) - 107055..107498 (+) 444 WP_012766439.1 zinc-dependent MarR family transcriptional regulator -
  MGCS35957_RS00685 (MGCS35957_00280) - 107502..108221 (+) 720 WP_022554112.1 metal ABC transporter ATP-binding protein -
  MGCS35957_RS00690 (MGCS35957_00282) - 108214..109026 (+) 813 WP_003055293.1 metal ABC transporter permease -
  MGCS35957_RS00695 (MGCS35957_00284) tyrS 109075..110331 (-) 1257 WP_084916949.1 tyrosine--tRNA ligase -
  MGCS35957_RS00700 (MGCS35957_00286) pbp1b 110438..112738 (+) 2301 WP_003059682.1 penicillin-binding protein PBP1B -
  MGCS35957_RS00705 (MGCS35957_00290) rpoB 113002..116568 (+) 3567 WP_049519675.1 DNA-directed RNA polymerase subunit beta -
  MGCS35957_RS00710 (MGCS35957_00292) rpoC 116664..120305 (+) 3642 WP_037589802.1 DNA-directed RNA polymerase subunit beta' -
  MGCS35957_RS00715 (MGCS35957_00294) - 120508..120873 (+) 366 WP_003055257.1 DUF1033 family protein -
  MGCS35957_RS00720 (MGCS35957_00296) comGA/cglA 120954..121895 (+) 942 WP_014611930.1 competence type IV pilus ATPase ComGA Machinery gene
  MGCS35957_RS00725 (MGCS35957_00298) comGB 121831..122862 (+) 1032 Protein_107 competence type IV pilus assembly protein ComGB -
  MGCS35957_RS00730 (MGCS35957_00300) comYC 122864..123190 (+) 327 WP_084916953.1 competence type IV pilus major pilin ComGC Machinery gene

Sequence

Protein


Download         Length: 108 a.a.        Molecular weight: 12439.42 Da        Isoelectric Point: 9.2972

>NTDB_id=783360 MGCS35957_RS00730 WP_084916953.1 122864..123190(+) (comYC) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957]
MKNQWKPLRQYQLQAFTLLEMLLVILVISVLMLLFVPNLSKQKDRVTETGNAAVVKLVENQAELYELSQGSKPSLQQLKD
DGSITDKQVKAYTDYYGKHRDETQKLQP

Nucleotide


Download         Length: 327 bp        

>NTDB_id=783360 MGCS35957_RS00730 WP_084916953.1 122864..123190(+) (comYC) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957]
ATGAAAAACCAATGGAAACCATTACGGCAATACCAACTACAAGCTTTCACACTTCTAGAAATGTTACTGGTGATTTTAGT
CATCAGTGTCTTAATGCTCTTATTTGTACCTAATTTAAGCAAACAAAAAGATAGGGTTACCGAAACAGGAAATGCTGCTG
TTGTCAAATTAGTGGAGAATCAAGCAGAGTTGTACGAATTATCGCAAGGATCAAAACCAAGTTTACAACAGTTGAAAGAC
GATGGCAGTATTACAGATAAACAGGTAAAAGCTTACACAGACTATTATGGAAAACACAGAGATGAAACTCAAAAACTACA
ACCTTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYC Streptococcus gordonii str. Challis substr. CH1

58.095

97.222

0.565
  comGC/cglC Streptococcus mitis SK321

52.83

98.148

0.519
  comGC/cglC Streptococcus pneumoniae D39

51.887

98.148

0.509
  comGC/cglC Streptococcus pneumoniae R6

51.887

98.148

0.509
  comGC/cglC Streptococcus pneumoniae Rx1

51.887

98.148

0.509
  comGC/cglC Streptococcus pneumoniae TIGR4

51.402

99.074

0.509
  comGC Lactococcus lactis subsp. cremoris KW2

53.398

95.37

0.509
  comGC/cglC Streptococcus mitis NCTC 12261

55.102

90.741

0.5
  comYC Streptococcus mutans UA140

52.475

93.519

0.491
  comYC Streptococcus mutans UA159

52.475

93.519

0.491
  comYC Streptococcus suis isolate S10

50.562

82.407

0.417