Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   PHA78_RS00800 Genome accession   NZ_CP116604
Coordinates   137433..138383 (+) Length   316 a.a.
NCBI ID   WP_043026808.1    Uniprot ID   -
Organism   Streptococcus sp. HN38     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 107951..138383 137433..138383 within 0


Gene organization within MGE regions


Location: 107951..138383
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PHA78_RS00680 - 107951..109099 (-) 1149 WP_024377200.1 site-specific integrase -
  PHA78_RS00685 - 109151..109492 (-) 342 WP_024376319.1 DUF771 domain-containing protein -
  PHA78_RS00690 - 109550..110788 (-) 1239 WP_024376318.1 replication initiation factor domain-containing protein -
  PHA78_RS00695 - 110882..111649 (-) 768 WP_099806850.1 AAA family ATPase -
  PHA78_RS00700 - 111649..112134 (-) 486 WP_024376316.1 hypothetical protein -
  PHA78_RS00705 - 112697..113404 (+) 708 WP_024376314.1 hypothetical protein -
  PHA78_RS00710 - 113461..113796 (-) 336 WP_306508887.1 helix-turn-helix transcriptional regulator -
  PHA78_RS00715 - 113943..116426 (+) 2484 WP_272158316.1 SEC10/PgrA surface exclusion domain-containing protein -
  PHA78_RS00720 - 116730..117350 (+) 621 WP_024376311.1 hypothetical protein -
  PHA78_RS00725 - 117520..117663 (+) 144 WP_099806715.1 putative holin-like toxin -
  PHA78_RS00730 - 118369..118812 (+) 444 WP_024377807.1 zinc-dependent MarR family transcriptional regulator -
  PHA78_RS00735 - 118813..119517 (+) 705 WP_024377806.1 metal ABC transporter ATP-binding protein -
  PHA78_RS00740 - 119510..120322 (+) 813 WP_002936593.1 metal ABC transporter permease -
  PHA78_RS00745 - 120332..121846 (+) 1515 WP_099778505.1 zinc ABC transporter substrate-binding protein AdcA -
  PHA78_RS00750 - 121949..122395 (+) 447 WP_024377804.1 CopY/TcrY family copper transport repressor -
  PHA78_RS00755 - 122392..122601 (+) 210 WP_024377803.1 heavy metal-associated domain-containing protein -
  PHA78_RS00760 - 122629..123006 (-) 378 WP_272158317.1 HIT family protein -
  PHA78_RS00765 - 123060..123842 (-) 783 WP_024377801.1 TMEM175 family protein -
  PHA78_RS00770 tyrS 123846..125102 (-) 1257 WP_024415510.1 tyrosine--tRNA ligase -
  PHA78_RS00775 pbp1b 125256..127679 (+) 2424 WP_272158318.1 penicillin-binding protein PBP1B -
  PHA78_RS00780 rpoB 128344..131916 (+) 3573 WP_002936570.1 DNA-directed RNA polymerase subunit beta -
  PHA78_RS00785 rpoC 132094..135741 (+) 3648 WP_272158319.1 DNA-directed RNA polymerase subunit beta' -
  PHA78_RS00790 - 135893..136252 (+) 360 WP_024377796.1 DUF1033 family protein -
  PHA78_RS00795 - 136397..137347 (-) 951 WP_272158320.1 S66 peptidase family protein -
  PHA78_RS00800 comYA 137433..138383 (+) 951 WP_043026808.1 competence type IV pilus ATPase ComGA Machinery gene

Sequence

Protein


Download         Length: 316 a.a.        Molecular weight: 35487.24 Da        Isoelectric Point: 5.0469

>NTDB_id=778743 PHA78_RS00800 WP_043026808.1 137433..138383(+) (comYA) [Streptococcus sp. HN38]
MIQEKARKMIEEAVADRVSDIYLVPRGECYQVYHRIMDEREFVQDVAEEEVTAIISHFKFLAGLNVGEKRRSQQGSCDYD
YGSGEISLRLSTVGDYRGKESLVIRLLYDNDKELKFWFEAAERLAEEIKGRGLYLFSGPVGSGKTTLMYHLARLKFPDKQ
ILTIEDPVEIKQEDMLQLQLNEAIGATYDNLIKLSLRHRPDLLIIGEIRDAETARAVIRASLTGATVFSTVHARSISGVY
ARMLELGVSPEELNNALQGIAYQRLIGGGGVVDFANGDYQNHSADQWNEQIDRLFAAGHISLRQAETEKITLGSPA

Nucleotide


Download         Length: 951 bp        

>NTDB_id=778743 PHA78_RS00800 WP_043026808.1 137433..138383(+) (comYA) [Streptococcus sp. HN38]
ATGATTCAAGAAAAAGCAAGAAAGATGATTGAAGAGGCGGTGGCAGATAGGGTCAGTGACATCTATCTAGTTCCTCGAGG
TGAGTGTTACCAAGTCTATCATCGTATCATGGACGAGCGGGAATTTGTGCAAGACGTGGCTGAGGAGGAAGTAACAGCCA
TCATCAGCCATTTCAAGTTTTTAGCAGGTTTAAATGTTGGTGAAAAACGCCGTAGCCAGCAGGGTTCCTGTGACTATGAT
TATGGGAGCGGAGAGATTTCGCTTCGCTTATCAACAGTCGGTGATTATCGTGGCAAGGAAAGTCTGGTTATCCGCCTGCT
CTATGACAATGACAAGGAACTCAAGTTCTGGTTTGAGGCGGCCGAGCGACTTGCAGAAGAAATCAAGGGACGAGGGCTCT
ACCTTTTTTCGGGTCCAGTCGGCTCTGGTAAGACCACACTTATGTACCATCTTGCCAGGCTGAAATTCCCAGACAAGCAG
ATTTTGACCATTGAAGATCCAGTCGAAATCAAGCAGGAGGACATGCTGCAACTCCAGCTCAATGAAGCCATCGGAGCCAC
CTACGATAATCTGATTAAACTGTCCCTCCGTCATCGACCGGACCTGCTCATCATCGGTGAAATTCGGGATGCAGAAACGG
CTCGAGCAGTCATTCGAGCCAGCCTGACGGGAGCTACCGTTTTCTCAACGGTTCATGCAAGGTCTATTTCGGGTGTTTAT
GCTCGTATGTTGGAATTGGGGGTCAGCCCCGAGGAGTTAAATAATGCCCTTCAAGGCATTGCATATCAACGCTTGATCGG
GGGAGGAGGTGTAGTGGATTTTGCAAATGGAGACTACCAAAACCATTCCGCAGACCAGTGGAATGAACAAATTGATCGCC
TTTTTGCAGCAGGACATATCAGTCTTCGGCAGGCAGAAACAGAAAAAATTACCCTTGGCTCGCCAGCGTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(8-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus gordonii str. Challis substr. CH1

68.71

98.101

0.674
  comYA Streptococcus mutans UA159

67.846

98.418

0.668
  comYA Streptococcus mutans UA140

67.846

98.418

0.668
  comGA/cglA/cilD Streptococcus pneumoniae D39

65.916

98.418

0.649
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

65.916

98.418

0.649
  comGA/cglA/cilD Streptococcus pneumoniae R6

65.916

98.418

0.649
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

65.916

98.418

0.649
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

65.595

98.418

0.646
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

65.161

98.101

0.639
  comGA Lactococcus lactis subsp. cremoris KW2

53.628

100

0.538