Detailed information NTG0071836

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EL277_RS11630
• Genome accession: NZ_AP018936
• Coordinates: 2175232..2175984 (-)
• Length: 250 a.a.
• NCBI ID: WP_126443193.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain NU83127
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2170232..2180984

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL277_RS12480	-	2172666..2174268 (-)	1603	Protein_2142	YhgE/Pip family protein	-
EL277_RS11615 (SPNU_2192)	-	2174447..2174989 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EL277_RS11630 (SPNU_2195)	comE	2175232..2175984 (-)	753	WP_126443193.1	competence system response regulator transcription factor ComE	Regulator
EL277_RS11635 (SPNU_2196)	comD/comD2	2175981..2177306 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
EL277_RS11640 (SPNU_2197)	comC/comC2	2177327..2177452 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
EL277_RS11650 (SPNU_2199)	rlmH	2177734..2178213 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL277_RS11655 (SPNU_2200)	htrA	2178396..2179577 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EL277_RS11660 (SPNU_2201)	spo0J	2179635..2180393 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29986.36 Da
• Isoelectric Point: 6.5073

>NTDB_id=71836 EL277_RS11630 WP_126443193.1 2175232..2175984(-) (comE) [Streptococcus pneumoniae strain NU83127]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVVQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=71836 EL277_RS11630 WP_126443193.1 2175232..2175984(-) (comE) [Streptococcus pneumoniae strain NU83127]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGTTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98	100	0.98
comE	Streptococcus infantis strain Atu-4	90.8	100	0.908
comE/comE2	Streptococcus gordonii strain NCTC7865	62.4	100	0.624
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.4	100	0.624
comE/blpR	Streptococcus mutans UA159	40.891	98.8	0.404