Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   EL277_RS09940 Genome accession   NZ_AP018936
Coordinates   1864036..1865292 (-) Length   418 a.a.
NCBI ID   WP_000642718.1    Uniprot ID   P54184
Organism   Streptococcus pneumoniae strain NU83127     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1859036..1870292
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL277_RS09910 (SPNU_1875) - 1859095..1859301 (-) 207 WP_000366093.1 hypothetical protein -
  EL277_RS09915 - 1859288..1859449 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  EL277_RS09920 (SPNU_1876) lytA 1859807..1860763 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  EL277_RS09925 (SPNU_1877) - 1861139..1862509 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  EL277_RS09935 (SPNU_1878) recA 1862815..1863981 (-) 1167 WP_001085467.1 recombinase RecA Machinery gene
  EL277_RS09940 (SPNU_1879) cinA 1864036..1865292 (-) 1257 WP_000642718.1 competence/damage-inducible protein A Machinery gene
  EL277_RS09945 (SPNU_1880) brpA 1865377..1866393 (-) 1017 WP_000239283.1 biofilm formation/cell division transcriptional regulator BrpA -
  EL277_RS09950 (SPNU_1881) - 1866401..1866919 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  EL277_RS09955 (SPNU_1882) tsaE 1866909..1867352 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  EL277_RS09960 (SPNU_1883) comM 1867438..1868058 (-) 621 WP_000839908.1 hypothetical protein Regulator
  EL277_RS09970 (SPNU_1884) - 1868441..1869304 (-) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  EL277_RS12630 (SPNU_1885) - 1869496..1869666 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  EL277_RS09980 (SPNU_1886) pneA1 1869769..1869993 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  EL277_RS09985 (SPNU_1887) pneA2 1870000..1870188 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45091.48 Da        Isoelectric Point: 4.6027

>NTDB_id=71813 EL277_RS09940 WP_000642718.1 1864036..1865292(-) (cinA) [Streptococcus pneumoniae strain NU83127]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFTLRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=71813 EL277_RS09940 WP_000642718.1 1864036..1865292(-) (cinA) [Streptococcus pneumoniae strain NU83127]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGGCAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTACCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P54184

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

100

100

1
  cinA Streptococcus pneumoniae Rx1

99.282

100

0.993
  cinA Streptococcus pneumoniae R6

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.043

100

0.99
  cinA Streptococcus mitis SK321

93.541

100

0.935
  cinA Streptococcus mitis NCTC 12261

93.301

100

0.933
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

54.808

99.522

0.545
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment