Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MOP79_RS06935 Genome accession   NZ_CP102583
Coordinates   1363982..1365238 (+) Length   418 a.a.
NCBI ID   WP_000642701.1    Uniprot ID   Q04IM5
Organism   Streptococcus pneumoniae strain D39Mega17545     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1351911..1371152 1363982..1365238 within 0


Gene organization within MGE regions


Location: 1351911..1371152
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MOP79_RS06875 - 1351911..1354019 (-) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  MOP79_RS06880 - 1354016..1354945 (-) 930 WP_000912954.1 M50 family metallopeptidase -
  MOP79_RS06885 - 1354926..1355630 (-) 705 WP_001033170.1 flavodoxin family protein -
  MOP79_RS06890 - 1355980..1358970 (-) 2991 WP_000875575.1 type 2 lanthipeptide synthetase LanM family protein -
  MOP79_RS06895 pneA2 1359086..1359274 (-) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  MOP79_RS06900 pneA1 1359281..1359505 (-) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  MOP79_RS06905 - 1359608..1359778 (-) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  MOP79_RS06910 - 1359970..1360833 (+) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  MOP79_RS06915 comM 1361216..1361836 (+) 621 WP_000839908.1 hypothetical protein Regulator
  MOP79_RS06920 tsaE 1361922..1362365 (+) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  MOP79_RS06925 - 1362355..1362873 (+) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  MOP79_RS06930 - 1362881..1363897 (+) 1017 WP_000239282.1 LCP family protein -
  MOP79_RS06935 cinA 1363982..1365238 (+) 1257 WP_000642701.1 competence/damage-inducible protein A Machinery gene
  MOP79_RS06940 recA 1365293..1366459 (+) 1167 WP_001085462.1 recombinase RecA Machinery gene
  MOP79_RS06945 - 1366766..1368136 (+) 1371 WP_001036271.1 MATE family efflux transporter -
  MOP79_RS06950 lytA 1368512..1369468 (+) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  MOP79_RS06955 - 1369827..1370000 (+) 174 WP_000289349.1 helix-turn-helix domain-containing protein -
  MOP79_RS06960 - 1369987..1370193 (+) 207 WP_000366091.1 hypothetical protein -
  MOP79_RS06965 - 1370239..1370598 (+) 360 WP_000749822.1 ImmA/IrrE family metallo-endopeptidase -
  MOP79_RS06970 - 1370727..1371152 (+) 426 WP_000204065.1 hypothetical protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45064.41 Da        Isoelectric Point: 4.5211

>NTDB_id=717877 MOP79_RS06935 WP_000642701.1 1363982..1365238(+) (cinA) [Streptococcus pneumoniae strain D39Mega17545]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGATEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQVQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=717877 MOP79_RS06935 WP_000642701.1 1363982..1365238(+) (cinA) [Streptococcus pneumoniae strain D39Mega17545]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGGCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGTTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q04IM5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae D39

100

100

1
  cinA Streptococcus pneumoniae Rx1

99.761

100

0.998
  cinA Streptococcus pneumoniae R6

99.761

100

0.998
  cinA Streptococcus pneumoniae TIGR4

99.043

100

0.99
  cinA Streptococcus mitis SK321

93.062

100

0.931
  cinA Streptococcus mitis NCTC 12261

92.823

100

0.928
  cinA Streptococcus mutans UA159

70.335

100

0.703
  cinA Streptococcus suis isolate S10

54.567

99.522

0.543
  cinA Bacillus subtilis subsp. subtilis str. 168

44.976

100

0.45