Detailed information NTG0069316

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: MDRSPN_RS05485
• Genome accession: NZ_AP018391
• Coordinates: 1064720..1065370 (-)
• Length: 216 a.a.
• NCBI ID: WP_000387336.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain MDRSPN001
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1059720..1070370

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MDRSPN_RS05465 (MDRSPN_01042)	-	1060322..1061506 (-)	1185	WP_000655961.1	membrane protein	-
MDRSPN_RS05470 (MDRSPN_01043)	-	1061510..1062097 (-)	588	WP_000939881.1	ATP-binding cassette domain-containing protein	-
MDRSPN_RS11605	-	1062130..1062347 (-)	218	Protein_1049	hypothetical protein	-
MDRSPN_RS05480 (MDRSPN_01044)	comEC/celB	1062496..1064736 (-)	2241	WP_000942405.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
MDRSPN_RS05485 (MDRSPN_01045)	comEA/celA/cilE	1064720..1065370 (-)	651	WP_000387336.1	ComEA family DNA-binding protein	Machinery gene
MDRSPN_RS05490 (MDRSPN_01046)	-	1065438..1066007 (-)	570	WP_000443774.1	GNAT family N-acetyltransferase	-
MDRSPN_RS11250	ald	1066184..1067295 (+)	1112	Protein_1053	alanine dehydrogenase	-
MDRSPN_RS05510 (MDRSPN_01049)	-	1067596..1067922 (-)	327	Protein_1054	TfoX/Sxy family protein	-
MDRSPN_RS05515 (MDRSPN_01050)	-	1067925..1068425 (-)	501	WP_000566986.1	GNAT family N-acetyltransferase	-
MDRSPN_RS05525 (MDRSPN_01051)	-	1068618..1069586 (-)	969	WP_000658183.1	PhoH family protein	-
MDRSPN_RS05530 (MDRSPN_01052)	-	1069671..1069886 (-)	216	WP_120164222.1	YozE family protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23189.54 Da
• Isoelectric Point: 5.5171

>NTDB_id=69316 MDRSPN_RS05485 WP_000387336.1 1064720..1065370(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain MDRSPN001]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=69316 MDRSPN_RS05485 WP_000387336.1 1064720..1065370(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain MDRSPN001]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae D39	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae R6	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.222	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	91.204	100	0.912
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361