Detailed information NTG0068729

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: KK0981_RS11565
• Genome accession: NZ_AP017971
• Coordinates: 2143103..2143855 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain KK0981
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2138103..2148855

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KK0981_RS12760	-	2140537..2142190 (-)	1654	Protein_2138	YhgE/Pip family protein	-
KK0981_RS11550 (KK0981_42490)	-	2142318..2142860 (+)	543	Protein_2139	TetR/AcrR family transcriptional regulator	-
KK0981_RS11565 (KK0981_42520)	comE	2143103..2143855 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
KK0981_RS11570 (KK0981_42530)	comD/comD1	2143852..2145177 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
KK0981_RS11575 (KK0981_42540)	comC/comC1	2145198..2145323 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
KK0981_RS11585 (KK0981_42560)	rlmH	2145605..2146084 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
KK0981_RS11590 (KK0981_42570)	htrA	2146267..2147448 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
KK0981_RS11595 (KK0981_42580)	spo0J	2147506..2148264 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=68729 KK0981_RS11565 WP_000866065.1 2143103..2143855(-) (comE) [Streptococcus pneumoniae strain KK0981]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=68729 KK0981_RS11565 WP_000866065.1 2143103..2143855(-) (comE) [Streptococcus pneumoniae strain KK0981]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408