Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MWH19_RS13930 Genome accession   NZ_CP095406
Coordinates   2824494..2825735 (+) Length   413 a.a.
NCBI ID   WP_012491282.1    Uniprot ID   A0A5Q8BSD6
Organism   Lacticaseibacillus paracasei strain GM-080     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2797526..2836816 2824494..2825735 within 0


Gene organization within MGE regions


Location: 2797526..2836816
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MWH19_RS13795 (MWH19_13770) - 2797526..2798524 (-) 999 WP_012490951.1 IS30 family transposase -
  MWH19_RS13800 (MWH19_13775) - 2798762..2800090 (-) 1329 WP_012491272.1 metallophosphoesterase -
  MWH19_RS13805 (MWH19_13780) - 2800281..2800547 (+) 267 WP_003564140.1 ACT domain-containing protein -
  MWH19_RS13810 (MWH19_13785) - 2800596..2801939 (+) 1344 WP_003657900.1 PFL family protein -
  MWH19_RS13815 (MWH19_13790) - 2802049..2803104 (+) 1056 WP_003569473.1 competence protein CoiA family protein -
  MWH19_RS13820 (MWH19_13795) - 2803294..2803929 (-) 636 WP_003601677.1 DsbA family protein -
  MWH19_RS13825 (MWH19_13800) - 2803999..2804592 (-) 594 WP_003601679.1 CYTH domain-containing protein -
  MWH19_RS13830 (MWH19_13805) - 2804786..2805457 (+) 672 WP_003564145.1 GTP pyrophosphokinase family protein -
  MWH19_RS13835 (MWH19_13810) - 2805459..2806256 (+) 798 WP_003564146.1 NAD kinase -
  MWH19_RS13840 (MWH19_13815) - 2806256..2807158 (+) 903 WP_012491275.1 RluA family pseudouridine synthase -
  MWH19_RS13845 (MWH19_13820) - 2807267..2808325 (-) 1059 WP_012491276.1 FAD:protein FMN transferase -
  MWH19_RS13850 (MWH19_13825) - 2808482..2809117 (-) 636 WP_003569480.1 copper homeostasis protein CutC -
  MWH19_RS13855 (MWH19_13830) - 2809139..2809957 (-) 819 WP_012491277.1 undecaprenyl-diphosphate phosphatase -
  MWH19_RS13860 (MWH19_13835) - 2810160..2811200 (-) 1041 WP_012491278.1 lactonase family protein -
  MWH19_RS13865 (MWH19_13840) - 2811472..2811849 (+) 378 WP_003564152.1 PTS glucitol/sorbitol transporter subunit IIA -
  MWH19_RS13870 (MWH19_13845) rpsN 2811961..2812230 (-) 270 WP_003564153.1 30S ribosomal protein S14 -
  MWH19_RS13875 (MWH19_13850) - 2812358..2813335 (-) 978 WP_024109435.1 GMP reductase -
  MWH19_RS13880 (MWH19_13855) - 2813575..2814522 (-) 948 WP_003564155.1 magnesium transporter CorA family protein -
  MWH19_RS13885 (MWH19_13860) - 2814588..2815430 (+) 843 WP_012491280.1 methyltransferase domain-containing protein -
  MWH19_RS13890 (MWH19_13865) trmL 2815685..2816194 (+) 510 WP_003564157.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
  MWH19_RS13895 (MWH19_13870) - 2816321..2816731 (+) 411 WP_003564159.1 DUF1149 family protein -
  MWH19_RS13900 (MWH19_13875) - 2816904..2819225 (+) 2322 WP_003604697.1 DNA translocase FtsK -
  MWH19_RS13905 (MWH19_13880) - 2819234..2820496 (+) 1263 WP_012491281.1 pitrilysin family protein -
  MWH19_RS13910 (MWH19_13885) - 2820493..2821785 (+) 1293 WP_003661348.1 pitrilysin family protein -
  MWH19_RS13915 (MWH19_13890) - 2821785..2822513 (+) 729 WP_003569514.1 SDR family oxidoreductase -
  MWH19_RS13920 (MWH19_13895) - 2822600..2823529 (+) 930 WP_003593861.1 helix-turn-helix domain-containing protein -
  MWH19_RS13925 (MWH19_13900) pgsA 2823526..2824119 (+) 594 WP_003564171.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  MWH19_RS13930 (MWH19_13905) cinA 2824494..2825735 (+) 1242 WP_012491282.1 competence/damage-inducible protein A Machinery gene
  MWH19_RS13935 (MWH19_13910) recA 2825792..2826853 (+) 1062 WP_003598111.1 recombinase RecA Machinery gene
  MWH19_RS13940 (MWH19_13915) rny 2827155..2828726 (+) 1572 WP_003657913.1 ribonuclease Y -
  MWH19_RS13945 (MWH19_13920) - 2828820..2829470 (-) 651 WP_012491283.1 YigZ family protein -
  MWH19_RS13950 (MWH19_13925) - 2829498..2830760 (+) 1263 WP_016379935.1 helicase-related protein -
  MWH19_RS13955 (MWH19_13930) - 2830973..2831434 (+) 462 WP_003583965.1 ComF family protein -
  MWH19_RS13960 (MWH19_13935) raiA 2831558..2832115 (+) 558 WP_003569531.1 ribosome-associated translation inhibitor RaiA -
  MWH19_RS13965 (MWH19_13940) secA 2832449..2834812 (+) 2364 WP_003578257.1 preprotein translocase subunit SecA -
  MWH19_RS13970 (MWH19_13945) prfB 2834937..2836053 (+) 1117 WP_096772597.1 peptide chain release factor 2 -
  MWH19_RS13975 (MWH19_13950) ftsE 2836130..2836816 (+) 687 WP_012491286.1 cell division ATP-binding protein FtsE -

Sequence

Protein


Download         Length: 413 a.a.        Molecular weight: 44326.69 Da        Isoelectric Point: 6.0028

>NTDB_id=676735 MWH19_RS13930 WP_012491282.1 2824494..2825735(+) (cinA) [Lacticaseibacillus paracasei strain GM-080]
MQAEIIAVGTEILMGQITNTNGAYMAKQLTALGIDSYHQQVVGDNGPRLEEAIKLAESRSNLVILIGGLGPTPDDLTKQT
LAAHLNRKLVEDPDAMAKLQARVKQQQRPMTPNNQLQAMYPEGADILVNRVGLAVGAWIVNGQHTYVLLPGPPKEFVPMV
DHELLPRLAKWSGHAEIMVSRVLRFFGIGESQLVTDLDDLIANQTDPTIATYIKDHEVTVRVTASGATEKDADAKLEPMI
GAIMDRDGQYFYGYGDDNSLAKELVKTLAANDMQITAAESLTAGAFQAALGDVPGVSTYFKGGFVTYSLATKAAFLAIDA
RELAAHGVVSAFTAKAMAEHARRKAAADISVSFTGVAGPDTLEGQPAGTVWIGLARRGQLPEAHVYHFPGGRNDVRQRAV
MTGMMLALRALQA

Nucleotide


Download         Length: 1242 bp        

>NTDB_id=676735 MWH19_RS13930 WP_012491282.1 2824494..2825735(+) (cinA) [Lacticaseibacillus paracasei strain GM-080]
ATGCAAGCAGAGATTATTGCTGTCGGGACAGAGATCCTGATGGGACAGATTACTAACACAAATGGTGCCTATATGGCTAA
GCAACTGACAGCACTGGGTATTGATAGCTACCATCAACAGGTGGTGGGAGACAACGGGCCGCGACTTGAGGAGGCCATTA
AGTTGGCGGAAAGTCGCAGTAATTTAGTTATTTTGATTGGCGGGTTAGGACCGACACCAGATGATCTGACCAAGCAAACA
TTGGCAGCGCACTTGAACCGCAAATTGGTTGAAGATCCTGACGCTATGGCTAAATTACAGGCGCGCGTCAAGCAACAGCA
GCGGCCAATGACGCCTAATAATCAATTACAGGCCATGTATCCGGAAGGCGCCGATATTTTGGTCAATCGGGTTGGCTTAG
CGGTTGGCGCGTGGATCGTCAATGGGCAGCACACCTATGTCTTATTGCCGGGACCACCGAAGGAATTCGTTCCGATGGTT
GATCATGAACTGCTGCCGCGGCTAGCAAAATGGAGCGGCCACGCGGAAATTATGGTCAGCCGGGTCTTACGTTTCTTTGG
CATTGGCGAATCGCAACTAGTGACAGATCTGGACGACTTGATTGCCAACCAAACCGATCCGACCATTGCAACTTATATCA
AGGATCATGAGGTGACGGTGCGCGTCACTGCCAGTGGCGCTACCGAAAAAGACGCTGATGCAAAGTTAGAACCAATGATC
GGTGCCATCATGGATCGTGATGGTCAATATTTTTACGGCTACGGTGACGACAATAGTTTGGCAAAAGAGCTTGTGAAGAC
GCTTGCGGCAAATGATATGCAAATTACTGCAGCTGAGAGTTTGACTGCTGGCGCATTTCAAGCAGCGTTAGGCGATGTGC
CGGGGGTATCCACTTATTTTAAGGGCGGTTTTGTCACTTACTCACTTGCAACAAAGGCCGCTTTTTTGGCAATTGATGCT
CGCGAATTAGCGGCACACGGAGTTGTCAGCGCATTTACAGCCAAGGCGATGGCTGAACATGCTCGGCGTAAGGCAGCGGC
GGATATAAGTGTCAGCTTTACCGGCGTTGCCGGTCCAGACACGCTGGAAGGACAGCCTGCTGGTACGGTTTGGATCGGTT
TAGCGCGGCGCGGCCAACTGCCTGAAGCACATGTTTACCATTTTCCTGGCGGTCGCAATGATGTTCGGCAGCGTGCTGTG
ATGACTGGTATGATGCTTGCATTAAGGGCGCTGCAGGCCTAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(258-410)

Damage-inducible protein CinA KH domain (CinA_KH)

(180-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5Q8BSD6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis NCTC 12261

51.887

100

0.533
  cinA Streptococcus mitis SK321

51.773

100

0.53
  cinA Streptococcus pneumoniae TIGR4

51.415

100

0.528
  cinA Streptococcus mutans UA159

52.174

100

0.523
  cinA Streptococcus pneumoniae Rx1

50.943

100

0.523
  cinA Streptococcus pneumoniae R6

50.943

100

0.523
  cinA Streptococcus pneumoniae D39

50.708

100

0.521
  cinA Bacillus subtilis subsp. subtilis str. 168

45.012

99.516

0.448
  cinA Streptococcus suis isolate S10

42.063

91.525

0.385