Detailed information    

insolico Bioinformatically predicted

Overview


Name   clpP   Type   Regulator
Locus tag   MUY23_RS02940 Genome accession   NZ_CP095162
Coordinates   600352..600942 (+) Length   196 a.a.
NCBI ID   WP_002937303.1    Uniprot ID   A0A0K2E545
Organism   Streptococcus suis strain TJS75     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 600352..634889 600352..600942 within 0


Gene organization within MGE regions


Location: 600352..634889
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MUY23_RS02940 clpP 600352..600942 (+) 591 WP_002937303.1 ATP-dependent Clp protease proteolytic subunit Regulator
  MUY23_RS02945 - 601069..601341 (+) 273 WP_002937299.1 YlbG family protein -
  MUY23_RS02950 - 601472..602641 (+) 1170 WP_002937297.1 ABC transporter substrate-binding protein -
  MUY23_RS02955 - 602847..603734 (+) 888 WP_002937296.1 branched-chain amino acid ABC transporter permease -
  MUY23_RS02960 - 603737..604684 (+) 948 WP_002937293.1 branched-chain amino acid ABC transporter permease -
  MUY23_RS02965 - 604684..605448 (+) 765 WP_002937291.1 ABC transporter ATP-binding protein -
  MUY23_RS02970 - 605448..606158 (+) 711 WP_002937288.1 ABC transporter ATP-binding protein -
  MUY23_RS02975 - 606529..607284 (+) 756 WP_002937287.1 epoxyqueuosine reductase QueH -
  MUY23_RS02980 - 607392..607982 (+) 591 WP_013730461.1 hypothetical protein -
  MUY23_RS02985 holA 608132..609163 (+) 1032 WP_024381608.1 DNA polymerase III subunit delta -
  MUY23_RS02990 sodA 609276..609881 (+) 606 WP_024381607.1 superoxide dismutase SodA -
  MUY23_RS02995 - 610143..612167 (+) 2025 WP_023370923.1 bifunctional metallophosphatase/5'-nucleotidase -
  MUY23_RS03005 - 612474..613568 (-) 1095 WP_061286144.1 tyrosine-type recombinase/integrase -
  MUY23_RS03010 - 613694..614128 (-) 435 WP_014636688.1 type II toxin-antitoxin system PemK/MazF family toxin -
  MUY23_RS03015 - 614303..615058 (-) 756 WP_024417671.1 XRE family transcriptional regulator -
  MUY23_RS03020 - 615201..615365 (+) 165 WP_153308570.1 hypothetical protein -
  MUY23_RS03025 - 615514..615819 (+) 306 WP_029743813.1 ImmA/IrrE family metallo-endopeptidase -
  MUY23_RS11750 - 615809..615937 (-) 129 WP_255199034.1 hypothetical protein -
  MUY23_RS03030 - 616080..616280 (+) 201 WP_024417669.1 helix-turn-helix transcriptional regulator -
  MUY23_RS03035 - 616295..616480 (+) 186 WP_004194666.1 helix-turn-helix transcriptional regulator -
  MUY23_RS03040 - 616516..616737 (+) 222 WP_004195135.1 hypothetical protein -
  MUY23_RS11755 - 616751..616882 (+) 132 WP_255199035.1 hypothetical protein -
  MUY23_RS03045 - 616833..617522 (-) 690 WP_014636681.1 DUF4145 domain-containing protein -
  MUY23_RS03050 - 617576..618286 (+) 711 WP_014636680.1 phage antirepressor KilAC domain-containing protein -
  MUY23_RS03055 - 618641..618898 (+) 258 WP_014636678.1 hypothetical protein -
  MUY23_RS03060 - 618879..619103 (+) 225 WP_004194648.1 hypothetical protein -
  MUY23_RS03065 - 619156..619521 (+) 366 WP_004194647.1 hypothetical protein -
  MUY23_RS03070 - 619842..619985 (+) 144 WP_014636677.1 hypothetical protein -
  MUY23_RS11760 - 619996..620124 (+) 129 WP_014636676.1 hypothetical protein -
  MUY23_RS03075 - 620124..620303 (+) 180 WP_004195116.1 hypothetical protein -
  MUY23_RS03080 bet 620300..621070 (+) 771 WP_044769722.1 phage recombination protein Bet -
  MUY23_RS03085 - 621080..622108 (+) 1029 WP_014636674.1 DUF1351 domain-containing protein -
  MUY23_RS03090 - 622111..622380 (+) 270 WP_002937957.1 hypothetical protein -
  MUY23_RS03095 - 622390..622716 (+) 327 WP_002937956.1 hypothetical protein -
  MUY23_RS03100 - 622706..622885 (+) 180 WP_002937955.1 hypothetical protein -
  MUY23_RS03105 ssbA 622988..623425 (+) 438 WP_341643189.1 single-stranded DNA-binding protein Machinery gene
  MUY23_RS03110 - 623453..623827 (+) 375 WP_002937949.1 hypothetical protein -
  MUY23_RS03115 - 624140..624472 (+) 333 WP_002937944.1 hypothetical protein -
  MUY23_RS03120 - 624469..624987 (+) 519 WP_002937943.1 hypothetical protein -
  MUY23_RS03125 - 625042..625299 (+) 258 WP_230334151.1 DUF1372 family protein -
  MUY23_RS03130 - 625315..625548 (+) 234 WP_002937935.1 hypothetical protein -
  MUY23_RS03135 - 625548..625724 (+) 177 WP_002937925.1 hypothetical protein -
  MUY23_RS03140 - 625724..625993 (+) 270 WP_002937922.1 hypothetical protein -
  MUY23_RS03145 - 626005..626256 (+) 252 WP_002937919.1 hypothetical protein -
  MUY23_RS03150 - 626333..626767 (+) 435 WP_002937915.1 DUF1492 domain-containing protein -
  MUY23_RS03155 - 626864..627211 (+) 348 WP_002937914.1 HNH endonuclease signature motif containing protein -
  MUY23_RS03160 - 627290..627652 (+) 363 WP_002937910.1 hypothetical protein -
  MUY23_RS03165 - 627649..628914 (+) 1266 WP_002937907.1 phage portal protein -
  MUY23_RS03170 - 628907..629308 (+) 402 Protein_609 hypothetical protein -
  MUY23_RS03175 - 629493..630695 (-) 1203 WP_002935596.1 IS110 family transposase -
  MUY23_RS03180 prx 631082..631297 (+) 216 WP_024395066.1 hypothetical protein Regulator
  MUY23_RS03185 - 631416..632630 (-) 1215 WP_024390438.1 chloride channel protein -
  MUY23_RS03190 - 632620..632898 (-) 279 WP_013730456.1 chorismate mutase -
  MUY23_RS03195 rpsN 632980..633249 (-) 270 WP_002940393.1 30S ribosomal protein S14 -
  MUY23_RS03200 - 633389..633850 (-) 462 WP_012775265.1 flavodoxin -
  MUY23_RS03205 - 633945..634889 (+) 945 WP_013730455.1 bifunctional oligoribonuclease/PAP phosphatase NrnA -

Sequence


Protein


Download         Length: 196 a.a.        Molecular weight: 21494.74 Da        Isoelectric Point: 5.7110

>NTDB_id=675829 MUY23_RS02940 WP_002937303.1 600352..600942(+) (clpP) [Streptococcus suis strain TJS75]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDPTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGTAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNKLEKILADNSGK
TVKQIHKDAERDYWMSAEETLAYGFIDQIMDNTKVK

Nucleotide


Download         Length: 591 bp        

>NTDB_id=675829 MUY23_RS02940 WP_002937303.1 600352..600942(+) (clpP) [Streptococcus suis strain TJS75]
ATGATTCCAGTAGTTATTGAACAAACTAGCCGTGGTGAGCGTTCTTATGATATTTACTCACGCCTTTTGAAAGACCGCAT
TATCATGTTGACAGGACCAGTTGAGGACAACATGGCAAACTCTATCATTGCACAATTGCTTTTCCTTGATGCCCAAGACC
CTACAAAGGATATTTACCTCTATGTTAATACGCCAGGAGGATCGGTGTCAGCAGGTCTTGCCATTGTAGACACGATGAAT
TTCATTAAAGCTGATGTTCAAACCATCGTTATGGGAACAGCTGCGAGCATGGGAACCATCATTGCATCAAGCGGTGCCAA
GGGCAAACGTTTCATGTTGCCAAATGCAGAGTACATGATTCACCAGCCAATGGGTGGAACTGGTGGTGGTACTCAGCAAA
CAGATATGGCTATTGCTGCAGAACACCTATTAAAAACACGTAATAAGCTAGAAAAAATCTTGGCAGACAACTCAGGTAAG
ACAGTCAAGCAAATCCACAAGGATGCAGAACGTGATTACTGGATGTCAGCTGAAGAAACCTTGGCTTATGGATTTATTGA
CCAGATTATGGACAATACAAAAGTCAAATAA

Domains


Predicted by InterproScan.

(11-192)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A0K2E545

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes JRS4

92.347

100

0.923

  clpP Streptococcus pyogenes MGAS315

92.347

100

0.923

  clpP Streptococcus mutans UA159

90.306

100

0.903

  clpP Streptococcus pneumoniae R6

88.776

100

0.888

  clpP Streptococcus pneumoniae Rx1

88.776

100

0.888

  clpP Streptococcus pneumoniae D39

88.776

100

0.888

  clpP Streptococcus pneumoniae TIGR4

88.776

100

0.888

  clpP Streptococcus thermophilus LMG 18311

88.776

100

0.888

  clpP Streptococcus thermophilus LMD-9

88.776

100

0.888

  clpP Lactococcus lactis subsp. lactis strain DGCC12653

84.184

100

0.842

  clpP Lactococcus lactis subsp. cremoris KW2

83.673

100

0.837

  clpP Bacillus subtilis subsp. subtilis str. 168

58.163

100

0.582

  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.549

98.469

0.577