Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   SRT_RS09890 Genome accession   NZ_AP014612
Coordinates   2022090..2023346 (-) Length   418 a.a.
NCBI ID   WP_128833942.1    Uniprot ID   A0A1L7LMB2
Organism   Streptococcus troglodytae strain TKU 31     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 2017090..2028346
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SRT_RS11190 - 2017090..2017218 (-) 129 WP_128833934.1 hypothetical protein -
  SRT_RS09845 (SRT_20010) - 2017286..2017585 (-) 300 WP_128833935.1 DUF1292 domain-containing protein -
  SRT_RS09850 (SRT_20020) ruvX 2017666..2018085 (-) 420 WP_128833936.1 Holliday junction resolvase RuvX -
  SRT_RS09855 (SRT_20030) - 2018082..2018351 (-) 270 WP_128833937.1 IreB family regulatory phosphoprotein -
  SRT_RS09860 brsR 2018519..2018954 (+) 436 Protein_1921 bacteriocin genes transcriptional regulator BrsR -
  SRT_RS09865 (SRT_20050) brsM 2018967..2019413 (+) 447 WP_128833938.1 bacteriocin genes regulator BrsM Regulator
  SRT_RS11295 - 2019404..2019597 (-) 194 Protein_1923 hypothetical protein -
  SRT_RS09875 (SRT_20060) - 2019739..2020164 (-) 426 WP_128833939.1 hypothetical protein -
  SRT_RS09880 (SRT_20070) spx 2020416..2020814 (-) 399 WP_128833940.1 transcriptional regulator Spx -
  SRT_RS09885 (SRT_20080) recA 2020899..2022050 (-) 1152 WP_128833941.1 recombinase RecA Machinery gene
  SRT_RS09890 (SRT_20090) cinA 2022090..2023346 (-) 1257 WP_128833942.1 competence/damage-inducible protein A Machinery gene
  SRT_RS09895 (SRT_20100) - 2023495..2024055 (-) 561 WP_128833943.1 DNA-3-methyladenine glycosylase I -
  SRT_RS09900 (SRT_20110) ruvA 2024137..2024730 (-) 594 WP_128834076.1 Holliday junction branch migration protein RuvA -
  SRT_RS09905 (SRT_20120) mutL 2024913..2026868 (-) 1956 WP_128833944.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45719.53 Da        Isoelectric Point: 6.9797

>NTDB_id=66196 SRT_RS09890 WP_128833942.1 2022090..2023346(-) (cinA) [Streptococcus troglodytae strain TKU 31]
MKSEIIAVGTEILTGQIVNTNSQFLSEKFAELGIDVYFQTAVGDNEERLLSVLKIAKERSDLIVLCGGLGPTEDDLTKQT
LAKFLKRELVFDKTAQERLDEFFASRPTSARTPNNECQAQIIAGSQPLSNETGLAVGGFLEADGVTYVVLPGPPSELKPM
VNKELLPYLSKTSEKLYSRVLRFFGIGESRLVTLLHDLIAKQTDPTIAPYAKTGEVTIRLSTKAHRQKEADSKLDKLEKK
IVAIDNLVDYFYGYGEENSLPQVVFDLLKERGKTITAAESLTAGLFQARLADFAGASDIFKGGFITYSIEEKARMLGIPL
EALQLHGVVSAFTAEKMAERSRRLTQSDLAVSLTGVAGPDSLESQPAGTVFIGLSSSKRTMAIKVLIGGRSRSDVRYIAV
LHAFNLVRQTLLSHKNLV

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=66196 SRT_RS09890 WP_128833942.1 2022090..2023346(-) (cinA) [Streptococcus troglodytae strain TKU 31]
ATGAAATCTGAGATCATTGCTGTTGGAACGGAAATTTTAACAGGACAAATTGTTAATACTAATAGCCAATTTTTATCAGA
AAAATTCGCAGAATTAGGAATTGATGTTTATTTTCAAACAGCGGTTGGTGATAATGAAGAACGCCTTTTATCTGTTTTGA
AAATTGCAAAGGAACGTAGTGATTTAATCGTACTTTGTGGTGGTTTGGGACCAACAGAAGATGATTTAACAAAACAAACC
CTAGCAAAATTTTTGAAAAGAGAATTGGTGTTTGATAAAACAGCTCAGGAACGTCTAGATGAATTTTTTGCATCACGTCC
GACATCTGCGCGTACGCCAAATAATGAATGTCAGGCGCAGATTATAGCAGGAAGCCAGCCTTTATCTAATGAAACAGGCT
TAGCAGTTGGGGGGTTTTTGGAGGCAGATGGAGTGACTTATGTTGTGTTACCTGGTCCGCCTAGTGAATTGAAGCCGATG
GTTAACAAAGAGTTACTCCCTTATTTATCAAAAACTTCTGAGAAGCTTTATTCTCGTGTCTTACGCTTTTTTGGCATTGG
TGAGAGTCGTTTGGTGACCTTGTTGCATGACTTAATAGCGAAGCAAACAGATCCCACAATTGCTCCTTATGCTAAGACAG
GTGAGGTAACAATACGTTTATCAACAAAAGCCCATAGGCAGAAAGAAGCAGATAGTAAGTTAGATAAGTTGGAAAAGAAA
ATTGTAGCTATTGATAACTTGGTTGATTATTTTTATGGTTATGGTGAAGAAAACTCATTACCACAGGTTGTATTTGATCT
GCTTAAGGAAAGAGGTAAAACTATTACAGCAGCTGAAAGTTTAACAGCAGGCCTTTTTCAGGCAAGATTAGCAGATTTTG
CAGGAGCATCTGATATCTTTAAGGGAGGTTTTATAACTTACAGTATAGAAGAGAAGGCTAGAATGCTAGGTATTCCTCTT
GAAGCTCTCCAACTTCATGGTGTTGTTAGTGCTTTTACTGCTGAAAAGATGGCAGAGCGCTCGCGTCGGCTGACTCAATC
AGATTTAGCTGTTTCTTTAACAGGAGTTGCAGGCCCGGATAGCTTAGAAAGTCAGCCGGCAGGGACAGTTTTTATCGGTT
TGTCAAGTTCCAAAAGAACAATGGCAATCAAAGTGTTAATTGGCGGACGCAGTCGGTCTGATGTGCGTTATATCGCTGTT
TTACATGCTTTTAATTTAGTACGTCAAACTTTATTATCTCATAAAAATTTAGTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(259-411)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1L7LMB2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

96.411

100

0.964
  cinA Streptococcus mitis SK321

72.249

100

0.722
  cinA Streptococcus mitis NCTC 12261

71.77

100

0.718
  cinA Streptococcus pneumoniae TIGR4

71.053

100

0.711
  cinA Streptococcus pneumoniae Rx1

70.813

100

0.708
  cinA Streptococcus pneumoniae R6

70.813

100

0.708
  cinA Streptococcus pneumoniae D39

70.574

100

0.706
  cinA Streptococcus suis isolate S10

54.745

98.325

0.538
  cinA Bacillus subtilis subsp. subtilis str. 168

45.521

98.804

0.45

Multiple sequence alignment