Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   M3B_RS09545 Genome accession   NZ_AP014596
Coordinates   1823709..1824980 (-) Length   423 a.a.
NCBI ID   WP_011055089.1    Uniprot ID   A0A5S4TLN8
Organism   Streptococcus pyogenes strain M3-b     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1818709..1829980
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M3B_RS09520 (M3B_1926) - 1820680..1820985 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  M3B_RS09525 (M3B_1927) ruvX 1820997..1821416 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  M3B_RS09530 (M3B_1928) - 1821413..1821682 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  M3B_RS09535 (M3B_1929) spx 1821795..1822193 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  M3B_RS09540 (M3B_1930) recA 1822484..1823620 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  M3B_RS09545 (M3B_1931) cinA 1823709..1824980 (-) 1272 WP_011055089.1 competence/damage-inducible protein A Machinery gene
  M3B_RS09550 (M3B_1932) - 1825049..1825609 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  M3B_RS09555 (M3B_1933) ruvA 1825619..1826215 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  M3B_RS09560 (M3B_1934) - 1826217..1827437 (-) 1221 WP_011055090.1 MDR family MFS transporter -
  M3B_RS09565 (M3B_1935) mutL 1827448..1829430 (-) 1983 WP_002992189.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45951.67 Da        Isoelectric Point: 4.7648

>NTDB_id=66126 M3B_RS09545 WP_011055089.1 1823709..1824980(-) (cinA) [Streptococcus pyogenes strain M3-b]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKSITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
CYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=66126 M3B_RS09545 WP_011055089.1 1823709..1824980(-) (cinA) [Streptococcus pyogenes strain M3-b]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGTCAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
TGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TLN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment