NTDB

Overview

Name	covR	Type	Regulator
Locus tag	MK801_RS04220	Genome accession	NZ_CP092748
Coordinates	798255..798947 (+)	Length	230 a.a.
NCBI ID	WP_003130756.1	Uniprot ID	S6EZK2
Organism	Lactococcus lactis strain 17M1
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 793255..803947

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MK801_RS04185 (MK801_04185)	-	794042..794407 (+)	366	WP_254255780.1	metallophosphoesterase	-
MK801_RS04190 (MK801_04190)	-	794447..794878 (+)	432	WP_254255781.1	hypothetical protein	-
MK801_RS04195 (MK801_04195)	-	794991..795902 (+)	912	WP_254255782.1	CHAP domain-containing protein	-
MK801_RS04200 (MK801_04200)	-	796129..796491 (+)	363	WP_057720003.1	TIGR02328 family protein	-
MK801_RS04205 (MK801_04205)	-	796573..797037 (+)	465	WP_029344120.1	hypothetical protein	-
MK801_RS04210 (MK801_04210)	-	797193..797438 (+)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
MK801_RS04215 (MK801_04215)	-	797569..798099 (+)	531	WP_254255783.1	DUF177 domain-containing protein	-
MK801_RS04220 (MK801_04220)	covR	798255..798947 (+)	693	WP_003130756.1	response regulator transcription factor	Regulator
MK801_RS04225 (MK801_04225)	covS	798956..800431 (+)	1476	WP_254255784.1	ATP-binding protein	Regulator
MK801_RS04230 (MK801_04230)	-	800614..801855 (+)	1242	WP_057719997.1	ammonium transporter	-
MK801_RS04235 (MK801_04235)	-	801987..802328 (+)	342	WP_010906046.1	P-II family nitrogen regulator	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26684.36 Da Isoelectric Point: 5.1273

                                >NTDB_id=659969 MK801_RS04220 WP_003130756.1 798255..798947(+) (covR) [Lactococcus lactis strain 17M1]

MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=659969 MK801_RS04220 WP_003130756.1 798255..798947(+) (covR) [Lactococcus lactis strain 17M1]

ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG

CTATGCGACTGAGATTAAAGATAATGGTCGTTCCGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG

ACGGCGCGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT

TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT

CTTTCCGTGATCTTGTGATTGATAAAACGAATCGCACAGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG

TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA

GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	S6EZK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361

Detailed information NTG0659969