Detailed information NTG0646020

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: L1A18_RS10545
• Genome accession: NZ_CP090887
• Coordinates: 2057130..2057882 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain NP7536
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2052130..2062882

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A18_RS10700	-	2054563..2056166 (-)	1604	Protein_2049	YhgE/Pip domain-containing protein	-
L1A18_RS10530 (L1A18_10530)	-	2056345..2056887 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
L1A18_RS10545 (L1A18_10545)	comE	2057130..2057882 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
L1A18_RS10550 (L1A18_10550)	comD/comD1	2057879..2059204 (-)	1326	WP_015511364.1	competence system sensor histidine kinase ComD	Regulator
L1A18_RS10555 (L1A18_10555)	comC/comC1	2059225..2059350 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
L1A18_RS10565 (L1A18_10565)	rlmH	2059633..2060112 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
L1A18_RS10570 (L1A18_10570)	htrA	2060295..2061476 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
L1A18_RS10575 (L1A18_10575)	spo0J	2061534..2062292 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=646020 L1A18_RS10545 WP_000866065.1 2057130..2057882(-) (comE) [Streptococcus pneumoniae strain NP7536]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=646020 L1A18_RS10545 WP_000866065.1 2057130..2057882(-) (comE) [Streptococcus pneumoniae strain NP7536]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408