Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   SMSK321_RS10625 Genome accession   NZ_AEDT01000032
Coordinates   236340..237521 (+) Length   393 a.a.
NCBI ID   WP_000681589.1    Uniprot ID   A0A0F2DH46
Organism   Streptococcus mitis SK321     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 231340..242521
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMSK321_RS10610 (SMSK321_1633) - 232389..232931 (+) 543 WP_001158273.1 TetR/AcrR family transcriptional regulator -
  SMSK321_RS0102895 comE 233174..233926 (-) 753 WP_000866074.1 competence system response regulator transcription factor ComE Regulator
  SMSK321_RS10615 (SMSK321_1634) comD 233923..235248 (-) 1326 WP_001048129.1 competence system sensor histidine kinase ComD Regulator
  SMSK321_RS0102900 comC 235269..235394 (-) 126 WP_000799685.1 competence-stimulating peptide ComC Regulator
  SMSK321_RS10620 (SMSK321_1635) rlmH 235677..236156 (-) 480 WP_000695928.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SMSK321_RS10625 (SMSK321_1636) htrA 236340..237521 (+) 1182 WP_000681589.1 S1C family serine protease Regulator
  SMSK321_RS10630 (SMSK321_1637) spo0J 237579..238337 (+) 759 WP_000410371.1 ParB/RepB/Spo0J family partition protein Regulator
  SMSK321_RS10635 (SMSK321_1638) dnaA 238551..239912 (+) 1362 WP_000660604.1 chromosomal replication initiator protein DnaA -
  SMSK321_RS10640 (SMSK321_1639) dnaN 240071..241207 (+) 1137 WP_000581168.1 DNA polymerase III subunit beta -
  SMSK321_RS10645 (SMSK321_1640) - 241272..241466 (+) 195 WP_000285186.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41651.47 Da        Isoelectric Point: 6.1475

>NTDB_id=64521 SMSK321_RS10625 WP_000681589.1 236340..237521(+) (htrA) [Streptococcus mitis SK321]
MKHLKTFYKKGFQLLVVIVISFISGALGSFSINQLTQKSTVSTSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDLRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=64521 SMSK321_RS10625 WP_000681589.1 236340..237521(+) (htrA) [Streptococcus mitis SK321]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTATTAGTGGAGCCTT
GGGTAGCTTTTCAATAAACCAACTAACTCAAAAAAGTACTGTAAGTACCTCTAACAACAATAGTACTATTACACAGACTG
CCTATAAGAATGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCAGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGACAAAGAAGCTTACATCGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCCGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCCATTGCTATTGGTAGCCC
ATTGGGTTCTGAATATGCAAATACTGTCACTCAGGGTATTGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCAACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATCTTAGAAGACTGAATATTCCAAGTAACGTAACATCTGGTGTCGTT
GTTCGTTCTGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2DH46

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

98.982

100

0.99
  htrA Streptococcus pneumoniae Rx1

96.692

100

0.967
  htrA Streptococcus pneumoniae D39

96.692

100

0.967
  htrA Streptococcus pneumoniae R6

96.692

100

0.967
  htrA Streptococcus pneumoniae TIGR4

96.692

100

0.967
  htrA Streptococcus gordonii str. Challis substr. CH1

66.499

100

0.672
  htrA Streptococcus mutans UA159

54.569

100

0.547

Multiple sequence alignment