Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LK450_RS06880 Genome accession   NZ_CP085939
Coordinates   1402008..1403198 (-) Length   396 a.a.
NCBI ID   WP_003032033.1    Uniprot ID   I0S836
Organism   Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1397008..1408198
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK450_RS06855 (LK450_06855) - 1397600..1398100 (+) 501 WP_003032448.1 YehR family lipoprotein -
  LK450_RS06860 (LK450_06860) - 1398124..1398321 (-) 198 WP_003032456.1 DUF951 domain-containing protein -
  LK450_RS06865 (LK450_06865) dnaN 1398321..1399457 (-) 1137 WP_003032449.1 DNA polymerase III subunit beta -
  LK450_RS06870 (LK450_06870) dnaA 1399614..1400957 (-) 1344 WP_003032031.1 chromosomal replication initiator protein DnaA -
  LK450_RS06875 (LK450_06875) spo0J 1401186..1401953 (-) 768 WP_003032028.1 ParB/RepB/Spo0J family partition protein Regulator
  LK450_RS06880 (LK450_06880) htrA 1402008..1403198 (-) 1191 WP_003032033.1 S1C family serine protease Regulator
  LK450_RS06885 (LK450_06885) rlmH 1403392..1403871 (+) 480 WP_003032032.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LK450_RS06895 (LK450_06895) - 1404153..1404299 (+) 147 WP_003029519.1 bacteriocin -
  LK450_RS06900 (LK450_06900) comD/comD2 1404320..1405642 (+) 1323 WP_221739197.1 GHKL domain-containing protein Regulator
  LK450_RS06905 (LK450_06905) comE 1405642..1406391 (+) 750 WP_018543656.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41651.61 Da        Isoelectric Point: 9.4264

>NTDB_id=621420 LK450_RS06880 WP_003032033.1 1402008..1403198(-) (htrA) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=621420 LK450_RS06880 WP_003032033.1 1402008..1403198(-) (htrA) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S836

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.561

100

0.765
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.471

99.242

0.551