Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   SIR_RS13415 Genome accession   NC_022246
Coordinates   727297..728001 (+) Length   234 a.a.
NCBI ID   WP_021002681.1    Uniprot ID   T1ZDT6
Organism   Streptococcus intermedius B196     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 722297..733001
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS13395 (SIR_0715) - 722646..723863 (+) 1218 WP_277592649.1 multidrug efflux MFS transporter -
  SIR_RS19650 (SIR_0716) rpmG 723847..723996 (+) 150 WP_003034401.1 50S ribosomal protein L33 -
  SIR_RS13400 (SIR_0717) secG 724036..724269 (+) 234 WP_003024744.1 preprotein translocase subunit SecG -
  SIR_RS13405 (SIR_0718) rnr 724360..726496 (+) 2137 Protein_702 ribonuclease R -
  SIR_RS13410 (SIR_0719) smpB 726662..727129 (+) 468 WP_021002680.1 SsrA-binding protein SmpB -
  SIR_RS13415 (SIR_0720) comEA/celA/cilE 727297..728001 (+) 705 WP_021002681.1 helix-hairpin-helix domain-containing protein Machinery gene
  SIR_RS13420 (SIR_0721) comEC/celB 727985..730219 (+) 2235 WP_021002682.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  SIR_RS13425 (SIR_0722) - 730297..731010 (+) 714 WP_003072599.1 DUF805 domain-containing protein -
  SIR_RS13430 (SIR_0723) - 731450..732436 (+) 987 WP_021002683.1 Gfo/Idh/MocA family protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 25472.87 Da        Isoelectric Point: 9.1090

>NTDB_id=61873 SIR_RS13415 WP_021002681.1 727297..728001(+) (comEA/celA/cilE) [Streptococcus intermedius B196]
MLEVIVAKIKEYKILVALSLIGLIIAGFFMMTSKSARQSNVGDIVQETTNAKLERKETSTETKKKQQKEETESQKNLASE
ELEFLTVDVKGAVKNPGIYQLKKTSRINDAIQKAGGLTTDADSKSINLAQKLTDEAVIYVAAIGENVTNATSNNGQTLTK
DTNETAAQKGNKVNLNKANLSDLQSISGIGQKRAQDILDYREANGKFNSVDDLKNISGVGAKTLEKLKEYVTVD

Nucleotide


Download         Length: 705 bp        

>NTDB_id=61873 SIR_RS13415 WP_021002681.1 727297..728001(+) (comEA/celA/cilE) [Streptococcus intermedius B196]
ATGTTAGAGGTAATCGTCGCAAAAATCAAAGAGTATAAAATTTTAGTTGCTTTAAGTCTGATTGGTTTGATCATAGCAGG
ATTTTTTATGATGACTAGTAAATCTGCTAGACAATCTAATGTGGGAGATATTGTACAAGAGACCACAAATGCAAAACTAG
AACGGAAAGAAACTTCAACTGAAACGAAGAAAAAACAACAGAAAGAAGAAACAGAATCTCAAAAGAATTTAGCGAGTGAA
GAATTGGAATTTTTAACTGTAGATGTTAAAGGTGCTGTTAAAAATCCAGGTATTTATCAATTAAAAAAAACGAGCCGAAT
CAATGATGCTATCCAAAAAGCGGGTGGACTAACAACAGACGCTGACAGCAAATCTATCAATTTGGCTCAAAAACTAACAG
ATGAGGCTGTGATTTATGTGGCAGCTATAGGTGAAAATGTAACAAATGCTACAAGTAATAATGGACAAACTTTAACGAAA
GATACCAATGAAACTGCGGCACAAAAAGGGAATAAGGTCAATCTAAATAAGGCTAATTTGTCTGATTTACAGTCTATTTC
TGGTATCGGACAAAAGCGCGCCCAAGATATTTTAGATTATCGTGAGGCAAATGGAAAATTTAATTCTGTTGATGATCTTA
AAAATATATCAGGAGTTGGTGCTAAAACATTAGAGAAATTGAAAGAATATGTCACAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(169-232)

SLBB domain (SLBB)

(87-140)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZDT6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus mitis SK321

49.367

100

0.5
  comEA/celA/cilE Streptococcus mitis NCTC 12261

49.785

99.573

0.496
  comEA/celA/cilE Streptococcus pneumoniae Rx1

49.356

99.573

0.491
  comEA/celA/cilE Streptococcus pneumoniae R6

49.356

99.573

0.491
  comEA/celA/cilE Streptococcus pneumoniae D39

49.356

99.573

0.491
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

49.356

99.573

0.491
  comEA Streptococcus thermophilus LMD-9

42.128

100

0.423
  comEA Lactococcus lactis subsp. cremoris KW2

39.056

99.573

0.389

Multiple sequence alignment