Detailed information NTG0061698

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SANR_RS10945
• Genome accession: NC_022239
• Coordinates: 2231624..2232814 (+)
• Length: 396 a.a.
• NCBI ID: WP_003032033.1
• Uniprot ID: I0S836
• Organism: Streptococcus anginosus C238
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2226624..2237814

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SANR_RS10920 (SANR_2121)	comE/comE2	2228434..2229183 (-)	750	WP_003038257.1	competence system response regulator transcription factor ComE	Regulator
SANR_RS10925 (SANR_2122)	comD/comD2	2229183..2230505 (-)	1323	WP_003038254.1	GHKL domain-containing protein	Regulator
SANR_RS11380 (SANR_2123)	-	2230520..2230669 (-)	150	WP_003038250.1	bacteriocin	-
SANR_RS10940	rlmH	2230951..2231430 (-)	480	WP_004225060.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SANR_RS10945 (SANR_2125)	htrA	2231624..2232814 (+)	1191	WP_003032033.1	S1C family serine protease	Regulator
SANR_RS10950 (SANR_2126)	spo0J	2232869..2233636 (+)	768	WP_003038259.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41651.61 Da
• Isoelectric Point: 9.4264

>NTDB_id=61698 SANR_RS10945 WP_003032033.1 2231624..2232814(+) (htrA) [Streptococcus anginosus C238]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=61698 SANR_RS10945 WP_003032033.1 2231624..2232814(+) (htrA) [Streptococcus anginosus C238]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

3D structure

• AlphaFold DB: I0S836

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	75.561	100	0.765
htrA	Streptococcus mitis NCTC 12261	72.544	100	0.727
htrA	Streptococcus pneumoniae Rx1	72.292	100	0.725
htrA	Streptococcus pneumoniae D39	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.292	100	0.725
htrA	Streptococcus pneumoniae TIGR4	72.292	100	0.725
htrA	Streptococcus mutans UA159	55.471	99.242	0.551