Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   SANR_RS10925 Genome accession   NC_022239
Coordinates   2229183..2230505 (-) Length   440 a.a.
NCBI ID   WP_003038254.1    Uniprot ID   I0S833
Organism   Streptococcus anginosus C238     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2224183..2235505
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SANR_RS10905 (SANR_2118) - 2225511..2228087 (+) 2577 WP_004225037.1 YfhO family protein -
  SANR_RS10920 (SANR_2121) comE/comE2 2228434..2229183 (-) 750 WP_003038257.1 competence system response regulator transcription factor ComE Regulator
  SANR_RS10925 (SANR_2122) comD/comD2 2229183..2230505 (-) 1323 WP_003038254.1 GHKL domain-containing protein Regulator
  SANR_RS11380 (SANR_2123) - 2230520..2230669 (-) 150 WP_003038250.1 bacteriocin -
  SANR_RS10940 rlmH 2230951..2231430 (-) 480 WP_004225060.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SANR_RS10945 (SANR_2125) htrA 2231624..2232814 (+) 1191 WP_003032033.1 S1C family serine protease Regulator
  SANR_RS10950 (SANR_2126) spo0J 2232869..2233636 (+) 768 WP_003038259.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 440 a.a.        Molecular weight: 51780.50 Da        Isoelectric Point: 7.9865

>NTDB_id=61697 SANR_RS10925 WP_003038254.1 2229183..2230505(-) (comD/comD2) [Streptococcus anginosus C238]
MNLDKIFIIISFIIGILSFSIVHKKISKVKIIDFRFTLLCLCLFLFSSFINSINSLLAYLCLLLEPIIIYFYFYRFKKYE
KCISVFATFLIYSSVTTSETFFSVIISSVTGDKFVDRYWGLFYIFINIISLIFILKAIDYFKFNFKYFKKADFKENILQL
NFYLLFIHFVLNLSHWLSNMKNLNSFSSMIATICFLMFMSTLFYLQSIREKYEKEEQIKQKEREQLQLQKYTDEIVSLYN
EIRGFRHDYGGMLASFQSAIHTADIKEVERIYQEVLVNANLQLRSDKYTYFDLNNVGDSALRSVMTQTLFKTRDYNIELT
FEVKDFVKPLPIKLLDLVRMTSVLLNNAIEGAAESYQKTMNVSLVDLDTETILVIQNSRKKRPLDLEEIYQTDFSTKGEG
RGLGLSNIKEIINNYEGIILDTKIEDEYFTQVIRVRKEGL

Nucleotide


Download         Length: 1323 bp        

>NTDB_id=61697 SANR_RS10925 WP_003038254.1 2229183..2230505(-) (comD/comD2) [Streptococcus anginosus C238]
ATGAATCTGGATAAAATATTTATAATCATTTCTTTTATTATCGGAATTTTATCTTTTTCAATTGTTCATAAAAAAATTAG
TAAAGTGAAAATTATAGATTTTCGCTTTACTTTATTGTGCTTGTGTTTATTTTTATTTTCATCTTTTATAAATTCGATTA
ATTCCTTATTAGCCTATTTATGTTTATTATTAGAGCCTATTATAATTTACTTCTATTTTTATCGCTTTAAGAAATATGAG
AAGTGTATATCAGTTTTTGCAACCTTTTTAATTTATTCATCTGTAACTACCTCTGAAACCTTCTTTTCAGTTATTATTTC
TTCTGTTACAGGTGATAAGTTTGTTGATAGATACTGGGGATTGTTCTATATTTTTATCAATATTATTTCTTTAATTTTTA
TTTTAAAAGCAATTGATTATTTTAAGTTTAATTTTAAATATTTTAAAAAGGCGGATTTCAAAGAGAATATTTTGCAGTTA
AACTTTTATCTCTTATTTATTCATTTTGTATTAAATTTATCGCATTGGCTTAGTAACATGAAAAATTTAAATAGTTTTTC
TAGTATGATTGCTACAATTTGCTTTTTAATGTTTATGTCAACTTTATTCTACTTACAATCTATTCGTGAAAAGTATGAAA
AAGAAGAACAAATTAAACAAAAAGAACGAGAACAACTACAATTACAAAAATATACAGATGAAATAGTGAGTCTGTATAAT
GAAATTCGAGGTTTTCGTCATGATTATGGAGGAATGTTGGCAAGCTTCCAATCAGCCATTCATACAGCTGATATAAAAGA
AGTAGAGCGAATTTATCAGGAAGTGCTAGTAAATGCTAATTTACAACTTCGTTCAGATAAATATACGTATTTTGATTTAA
ATAATGTTGGAGATTCAGCACTTAGAAGTGTTATGACACAAACCTTATTTAAGACGCGTGACTATAATATAGAATTAACA
TTTGAAGTAAAAGATTTTGTCAAACCCTTGCCGATTAAATTGTTAGATTTGGTTAGAATGACAAGTGTCCTTTTAAATAA
TGCAATAGAGGGAGCGGCAGAAAGTTATCAAAAAACGATGAATGTTTCTTTAGTAGATCTGGATACAGAAACAATCTTAG
TTATTCAAAATTCACGTAAGAAACGACCGCTAGATTTAGAAGAGATTTACCAAACTGATTTTTCAACAAAGGGTGAAGGA
CGCGGTTTAGGCTTAAGCAATATCAAAGAAATTATTAACAACTATGAAGGAATTATCCTCGATACTAAAATTGAGGATGA
ATATTTTACACAAGTAATAAGAGTAAGGAAAGAAGGTTTATAA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-433)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S833

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus gordonii strain NCTC7865

55.056

100

0.557
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

59.115

87.273

0.516
  comD/comD1 Streptococcus pneumoniae R6

43.649

98.409

0.43
  comD/comD1 Streptococcus pneumoniae Rx1

43.649

98.409

0.43
  comD/comD1 Streptococcus pneumoniae D39

43.649

98.409

0.43
  comD Streptococcus mitis SK321

43.765

96.591

0.423
  comD Streptococcus mitis NCTC 12261

47.721

84.773

0.405
  comD/comD2 Streptococcus pneumoniae TIGR4

47.185

84.773

0.4

Multiple sequence alignment