Detailed information NTG0613834

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LB315_RS10170
• Genome accession: NZ_CP084892
• Coordinates: 2033529..2034572 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CC1956/ST4614-MSSA
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2028529..2039572

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LB315_RS10140 (LB315_10150)	-	2028950..2030206 (-)	1257	WP_001793428.1	aminopeptidase	-
LB315_RS10145 (LB315_10155)	-	2030209..2030409 (-)	201	WP_000180462.1	DUF1128 family protein	-
LB315_RS10150 (LB315_10160)	-	2030556..2031020 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LB315_RS10155 (LB315_10165)	-	2031027..2031302 (+)	276	WP_061738610.1	hypothetical protein	-
LB315_RS10160 (LB315_10170)	-	2031580..2032797 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
LB315_RS10165 (LB315_10175)	vraR	2032910..2033539 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
LB315_RS10170 (LB315_10180)	vraS	2033529..2034572 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LB315_RS10175 (LB315_10185)	liaF	2034569..2035270 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LB315_RS10180 (LB315_10190)	-	2035285..2035671 (-)	387	WP_001110179.1	hypothetical protein	-
LB315_RS10185 (LB315_10195)	map	2035888..2036646 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LB315_RS10190 (LB315_10200)	-	2037174..2038160 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
LB315_RS10195 (LB315_10205)	-	2038349..2038762 (-)	414	WP_078064660.1	hypothetical protein	-
LB315_RS10200 (LB315_10210)	-	2038791..2038903 (-)	113	Protein_1973	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=613834 LB315_RS10170 WP_001017131.1 2033529..2034572(-) (vraS) [Staphylococcus aureus strain CC1956/ST4614-MSSA]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=613834 LB315_RS10170 WP_001017131.1 2033529..2034572(-) (vraS) [Staphylococcus aureus strain CC1956/ST4614-MSSA]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACAAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1