Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   NPS18_RS02990 Genome accession   NZ_CP101984
Coordinates   583005..583682 (+) Length   225 a.a.
NCBI ID   WP_002261916.1    Uniprot ID   Q8DV80
Organism   Streptococcus mutans strain UA-159     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 578005..588682
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS18_RS02970 (NPS18_02970) - 579372..580391 (-) 1020 WP_002261920.1 GIY-YIG nuclease family protein -
  NPS18_RS02975 (NPS18_02975) - 580437..580949 (-) 513 WP_002261919.1 HXXEE domain-containing protein -
  NPS18_RS02980 (NPS18_02980) - 581038..581973 (-) 936 WP_002261918.1 polysaccharide deacetylase family protein -
  NPS18_RS02985 (NPS18_02985) - 582112..582864 (+) 753 WP_002261917.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  NPS18_RS02990 (NPS18_02990) comEA/celA/cilE 583005..583682 (+) 678 WP_002261916.1 helix-hairpin-helix domain-containing protein Machinery gene
  NPS18_RS02995 (NPS18_02995) comEC/celB 583672..585906 (+) 2235 WP_002261915.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  NPS18_RS03000 (NPS18_03000) - 586092..586718 (+) 627 WP_002261914.1 DUF805 domain-containing protein -
  NPS18_RS03005 (NPS18_03005) holA 586886..587926 (+) 1041 WP_002261913.1 DNA polymerase III subunit delta -

Sequence

Protein


Download         Length: 225 a.a.        Molecular weight: 24459.77 Da        Isoelectric Point: 8.2999

>NTDB_id=613598 NPS18_RS02990 WP_002261916.1 583005..583682(+) (comEA/celA/cilE) [Streptococcus mutans strain UA-159]
MVDEFLDKLKEKKNVFALVGGLVVLLGLGVYFFFPSSNKQEDSLARLKEQSLQVTTKTGKESQKKTQTTAKSTITVDIKG
AVKHEGVYTLPIDSRINDVIEKAGGFSEKADRKSVNLAQKLQDEAVIYVAAIGENISVIRDSQEGKTSQADKANTKETSV
KGKVNLNTATLADLQTISGIGEKKAQDILDYREANGGFKSVDDLKNISGIGDKTFEKLKDLVSVD

Nucleotide


Download         Length: 678 bp        

>NTDB_id=613598 NPS18_RS02990 WP_002261916.1 583005..583682(+) (comEA/celA/cilE) [Streptococcus mutans strain UA-159]
ATGGTTGACGAATTTTTAGATAAACTCAAGGAAAAGAAAAATGTTTTTGCCCTAGTTGGTGGTCTTGTAGTCTTACTGGG
TCTGGGTGTTTATTTCTTTTTTCCTTCTTCCAATAAGCAGGAAGATAGTCTGGCTCGTTTAAAGGAACAATCCCTTCAGG
TAACCACAAAGACTGGCAAAGAAAGTCAGAAGAAGACGCAGACGACTGCCAAATCAACAATAACTGTTGATATTAAAGGA
GCTGTTAAGCATGAGGGCGTCTATACTTTACCGATTGACAGTCGTATTAATGATGTAATAGAAAAAGCGGGAGGTTTTTC
TGAAAAGGCTGATCGCAAATCTGTTAATCTGGCTCAAAAATTACAAGACGAAGCAGTTATTTATGTGGCAGCTATTGGTG
AGAATATTAGTGTCATTAGGGATTCTCAAGAAGGTAAAACCAGTCAGGCAGATAAGGCAAATACTAAAGAAACTTCGGTA
AAAGGTAAGGTTAATCTTAATACTGCCACTTTGGCTGATTTACAGACTATTTCTGGAATCGGTGAGAAGAAAGCTCAGGA
TATTCTTGATTACCGTGAAGCCAATGGAGGTTTTAAGTCAGTGGATGATTTGAAAAATATTTCAGGGATTGGCGATAAAA
CATTTGAGAAGTTAAAGGATTTAGTCAGTGTTGATTAG

Domains

Predicted by InterProScan.

Helix-hairpin-helix motif (HHH_3)

(162-222)

SLBB domain (SLBB)

(76-129)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DV80

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

43.612

100

0.44
  comEA/celA/cilE Streptococcus mitis NCTC 12261

43.612

100

0.44
  comEA/celA/cilE Streptococcus pneumoniae R6

42.731

100

0.431
  comEA/celA/cilE Streptococcus pneumoniae D39

42.731

100

0.431
  comEA/celA/cilE Streptococcus pneumoniae Rx1

42.731

100

0.431
  comEA/celA/cilE Streptococcus mitis SK321

42.291

100

0.427
  comEA Lactococcus lactis subsp. cremoris KW2

42.222

100

0.422
  comEA Streptococcus thermophilus LMD-9

57.143

68.444

0.391
  comEA Latilactobacillus sakei subsp. sakei 23K

35.124

100

0.378
  comEA Bacillus subtilis subsp. subtilis str. 168

37.273

97.778

0.364