NTDB

Overview

Name	covR	Type	Regulator
Locus tag	I6G24_RS02390	Genome accession	NZ_CP084189
Coordinates	377102..377794 (+)	Length	230 a.a.
NCBI ID	WP_003130756.1	Uniprot ID	S6EZK2
Organism	Lactococcus lactis strain FDAARGOS_867
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 372102..382794

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G24_RS02360 (I6G24_02355)	-	373063..373899 (+)	837	WP_023164354.1	metallophosphoesterase	-
I6G24_RS02365 (I6G24_02360)	-	373960..374490 (+)	531	WP_003130764.1	CHAP domain-containing protein	-
I6G24_RS13850	-	374494..374625 (+)	132	WP_021722678.1	hypothetical protein	-
I6G24_RS02370 (I6G24_02365)	-	374976..375338 (+)	363	WP_010906050.1	TIGR02328 family protein	-
I6G24_RS02375 (I6G24_02370)	-	375420..375884 (+)	465	WP_003130761.1	hypothetical protein	-
I6G24_RS02380 (I6G24_02375)	-	376040..376285 (+)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
I6G24_RS02385 (I6G24_02380)	-	376416..376946 (+)	531	WP_023164353.1	DUF177 domain-containing protein	-
I6G24_RS02390 (I6G24_02385)	covR	377102..377794 (+)	693	WP_003130756.1	response regulator transcription factor	Regulator
I6G24_RS02395 (I6G24_02390)	covS	377803..379278 (+)	1476	WP_023164352.1	HAMP domain-containing histidine kinase	Regulator
I6G24_RS02400 (I6G24_02395)	-	379461..380702 (+)	1242	WP_023164351.1	ammonium transporter	-
I6G24_RS02405 (I6G24_02400)	-	380834..381175 (+)	342	WP_010906046.1	P-II family nitrogen regulator	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26684.36 Da Isoelectric Point: 5.1273

                                >NTDB_id=609933 I6G24_RS02390 WP_003130756.1 377102..377794(+) (covR) [Lactococcus lactis strain FDAARGOS_867]

MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=609933 I6G24_RS02390 WP_003130756.1 377102..377794(+) (covR) [Lactococcus lactis strain FDAARGOS_867]

ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG

CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG

ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT

TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT

CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG

TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATCCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA

GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	S6EZK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361

Detailed information NTG0609933