Detailed information NTG0602584

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: K8B76_RS10495
• Genome accession: NZ_CP082820
• Coordinates: 2092927..2093679 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain SCAID PHRX1-2021
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2087927..2098679

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K8B76_RS11065 (K8B76_10475)	-	2090403..2092014 (-)	1612	Protein_2053	YhgE/Pip family protein	-
K8B76_RS10480 (K8B76_10480)	-	2092142..2092684 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
K8B76_RS10495 (K8B76_10495)	comE	2092927..2093679 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
K8B76_RS10500 (K8B76_10500)	comD/comD2	2093676..2095001 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
K8B76_RS10505 (K8B76_10505)	comC/comC2	2095022..2095147 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
K8B76_RS10515 (K8B76_10515)	rlmH	2095429..2095908 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
K8B76_RS10520 (K8B76_10520)	htrA	2096091..2097272 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
K8B76_RS10525 (K8B76_10525)	spo0J	2097330..2098088 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=602584 K8B76_RS10495 WP_000866065.1 2092927..2093679(-) (comE) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=602584 K8B76_RS10495 WP_000866065.1 2092927..2093679(-) (comE) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408