Detailed information NTG0058139

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPN994038_RS10875
• Genome accession: NC_021026
• Coordinates: 2021050..2021802 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae SPN994038
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2016050..2026802

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN994038_RS13275	-	2018485..2020159 (-)	1675	Protein_2048	YhgE/Pip family protein	-
SPN994038_RS10860 (SPN994038_19680)	-	2020266..2020808 (+)	543	WP_001158255.1	TetR/AcrR family transcriptional regulator	-
SPN994038_RS10875 (SPN994038_19690)	comE	2021050..2021802 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPN994038_RS10880 (SPN994038_19700)	comD/comD1	2021799..2023124 (-)	1326	WP_014632435.1	competence system sensor histidine kinase ComD	Regulator
SPN994038_RS10885 (SPN994038_19710)	comC/comC1	2023145..2023270 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPN994038_RS10895 (SPN994038_19720)	rlmH	2023553..2024032 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPN994038_RS10900 (SPN994038_19730)	htrA	2024215..2025396 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
SPN994038_RS10905 (SPN994038_19740)	spo0J	2025454..2026212 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=58139 SPN994038_RS10875 WP_000866065.1 2021050..2021802(-) (comE) [Streptococcus pneumoniae SPN994038]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=58139 SPN994038_RS10875 WP_000866065.1 2021050..2021802(-) (comE) [Streptococcus pneumoniae SPN994038]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408