NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	I6L84_RS03375	Genome accession	NZ_CP077224
Coordinates	671900..672574 (+)	Length	224 a.a.
NCBI ID	WP_008808730.1	Uniprot ID	A0A0F2CMN1
Organism	Streptococcus gordonii strain FDAARGOS 1454
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 666900..677574

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6L84_RS03350 (I6L84_03350)	-	667208..667504 (+)	297	WP_060553645.1	hypothetical protein	-
I6L84_RS03355 (I6L84_03355)	-	667513..667839 (+)	327	WP_060553644.1	hypothetical protein	-
I6L84_RS03360 (I6L84_03360)	-	667970..670513 (+)	2544	WP_060553643.1	M1 family metallopeptidase	-
I6L84_RS03365 (I6L84_03365)	-	670570..671112 (-)	543	WP_060553642.1	biotin transporter BioY	-
I6L84_RS03370 (I6L84_03370)	-	671332..671769 (+)	438	WP_060553641.1	hypothetical protein	-
I6L84_RS03375 (I6L84_03375)	ciaR	671900..672574 (+)	675	WP_008808730.1	response regulator transcription factor	Regulator
I6L84_RS03380 (I6L84_03380)	ciaH	672564..673964 (+)	1401	WP_060553640.1	cell wall metabolism sensor histidine kinase WalK	Regulator
I6L84_RS03385 (I6L84_03385)	-	673966..674892 (+)	927	WP_060553639.1	ketopantoate reductase family protein	-
I6L84_RS03390 (I6L84_03390)	-	674916..676367 (-)	1452	WP_060553638.1	alpha-amylase	-
I6L84_RS03395 (I6L84_03395)	rpsT	676598..676846 (-)	249	WP_008808726.1	30S ribosomal protein S20	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25362.07 Da Isoelectric Point: 4.3228

                                >NTDB_id=580008 I6L84_RS03375 WP_008808730.1 671900..672574(+) (ciaR) [Streptococcus gordonii strain FDAARGOS 1454]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

Download Length: 675 bp

                                >NTDB_id=580008 I6L84_RS03375 WP_008808730.1 671900..672574(+) (ciaR) [Streptococcus gordonii strain FDAARGOS 1454]

ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCTGTATTTGATTTCTTAGATGACTTTGCAGATGT

CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC

TCCCTGAGAAAGATGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT

AAAGAAAGTTTGGATGATAAAGGGCATGGTTTTGAATTGGGTGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA

ATTAAAGATGCGGATTCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTATCATATGGTGATGTGACAG

TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT

TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGACTCTGGGGCTTTGACAGTGATACTACCAT

TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC

GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0F2CMN1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362

Detailed information NTG0580008