Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   J7U22_RS07540 Genome accession   NZ_CP072428
Coordinates   1453128..1454027 (-) Length   299 a.a.
NCBI ID   WP_014607953.1    Uniprot ID   A0AAN1ZWJ0
Organism   Streptococcus thermophilus strain S24749     
Function   activate transcription of comX; activate transcription of comS (predicted from homology)   
Competence regulation

Genomic Context

Location: 1448128..1459027
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J7U22_RS07495 (J7U22_07470) - 1448131..1448646 (-) 516 WP_002949547.1 AmiS/UreI family transporter -
  J7U22_RS07500 - 1449051..1449947 (+) 897 WP_224102957.1 urease cluster protein -
  J7U22_RS07505 - 1450187..1450471 (+) 285 WP_014727318.1 hypothetical protein -
  J7U22_RS07510 (J7U22_07480) - 1450434..1450751 (-) 318 WP_011225454.1 DUF805 domain-containing protein -
  J7U22_RS07515 (J7U22_07485) - 1450859..1451427 (-) 569 Protein_1456 ATP-binding cassette domain-containing protein -
  J7U22_RS07520 comA 1451482..1451691 (-) 210 WP_002946147.1 hypothetical protein Regulator
  J7U22_RS07525 (J7U22_07495) comA 1451713..1452003 (-) 291 WP_081004984.1 ABC transporter transmembrane domain-containing protein Regulator
  J7U22_RS07530 comA 1452034..1452444 (-) 411 WP_216593071.1 ABC transporter transmembrane domain-containing protein Regulator
  J7U22_RS07535 - 1452459..1452953 (-) 495 Protein_1460 cysteine peptidase family C39 domain-containing protein -
  J7U22_RS07540 (J7U22_07510) comR 1453128..1454027 (-) 900 WP_014607953.1 helix-turn-helix domain-containing protein Regulator
  J7U22_RS07545 (J7U22_07515) - 1454222..1454872 (-) 651 WP_011225447.1 phosphatase PAP2 family protein -
  J7U22_RS07550 (J7U22_07520) - 1454875..1455432 (-) 558 WP_002949523.1 ECF transporter S component -
  J7U22_RS07555 (J7U22_07525) - 1455744..1456253 (-) 510 WP_014607952.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
  J7U22_RS07560 (J7U22_07530) trkA 1456542..1457891 (+) 1350 WP_014607951.1 Trk system potassium transporter TrkA -

Sequence

Protein


Download         Length: 299 a.a.        Molecular weight: 35289.70 Da        Isoelectric Point: 5.0061

>NTDB_id=552592 J7U22_RS07540 WP_014607953.1 1453128..1454027(-) (comR) [Streptococcus thermophilus strain S24749]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide


Download         Length: 900 bp        

>NTDB_id=552592 J7U22_RS07540 WP_014607953.1 1453128..1454027(-) (comR) [Streptococcus thermophilus strain S24749]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(11-66)

ComR tetratricopeptide (ComR_TPR)

(75-292)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus thermophilus LMG 18311

99.666

100

0.997
  comR Streptococcus thermophilus LMD-9

98.997

100

0.99
  comR Streptococcus salivarius strain HSISS4

94.983

100

0.95
  comR Streptococcus salivarius SK126

94.314

100

0.943
  comR/comR2 Streptococcus sobrinus strain NIDR 6715-7

42.14

100

0.421
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

41.806

100

0.418