Detailed information NTG0541065

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: JWR96_RS03340
• Genome accession: NZ_CP070856
• Coordinates: 644956..645648 (+)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain GR0507
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 639956..650648

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JWR96_RS03310 (JWR96_03310)	arsC	640613..641017 (+)	405	WP_021165525.1	arsenate reductase (thioredoxin)	-
JWR96_RS03315 (JWR96_03315)	-	641129..641965 (+)	837	WP_043735256.1	metallophosphoesterase	-
JWR96_RS03320 (JWR96_03320)	-	642058..642969 (+)	912	WP_043735255.1	CHAP domain-containing protein	-
JWR96_RS03325 (JWR96_03325)	-	643205..643567 (+)	363	WP_043735253.1	TIGR02328 family protein	-
JWR96_RS03330 (JWR96_03330)	-	643891..644136 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
JWR96_RS03335 (JWR96_03335)	-	644269..644799 (+)	531	WP_011834860.1	DUF177 domain-containing protein	-
JWR96_RS03340 (JWR96_03340)	covR	644956..645648 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
JWR96_RS03345 (JWR96_03345)	covS	645661..647133 (+)	1473	WP_043735252.1	HAMP domain-containing histidine kinase	Regulator
JWR96_RS03350 (JWR96_03350)	-	647319..648560 (+)	1242	WP_043735251.1	ammonium transporter	-
JWR96_RS03355 (JWR96_03355)	-	648643..648984 (+)	342	WP_011676628.1	P-II family nitrogen regulator	-
JWR96_RS03360 (JWR96_03360)	murD	649152..650501 (+)	1350	WP_043735249.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=541065 JWR96_RS03340 WP_011676631.1 644956..645648(+) (covR) [Lactococcus cremoris strain GR0507]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=541065 JWR96_RS03340 WP_011676631.1 644956..645648(+) (covR) [Lactococcus cremoris strain GR0507]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGTCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGTGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TATGACCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361