Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   JQM34_RS06860 Genome accession   NZ_CP069427
Coordinates   1437836..1439032 (-) Length   398 a.a.
NCBI ID   WP_000681800.1    Uniprot ID   A0A3R9IBN0
Organism   Streptococcus oralis strain SF100     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1432836..1444032
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JQM34_RS06840 (JQM34_0001395) - 1433888..1434082 (-) 195 WP_000285184.1 DUF951 family protein -
  JQM34_RS06845 (JQM34_0001396) dnaN 1434147..1435283 (-) 1137 WP_000581146.1 DNA polymerase III subunit beta -
  JQM34_RS06850 (JQM34_0001397) dnaA 1435442..1436803 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  JQM34_RS06855 (JQM34_0001398) spo0J 1437020..1437778 (-) 759 WP_200370607.1 ParB/RepB/Spo0J family partition protein Regulator
  JQM34_RS06860 (JQM34_0001399) htrA 1437836..1439032 (-) 1197 WP_000681800.1 S1C family serine protease Regulator
  JQM34_RS06865 (JQM34_0001400) rlmH 1439218..1439697 (+) 480 WP_200370609.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  JQM34_RS06875 (JQM34_0001402) comC/comC2 1439979..1440104 (+) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  JQM34_RS06880 (JQM34_0001403) comD 1440125..1441444 (+) 1320 WP_000362886.1 competence system sensor histidine kinase ComD Regulator
  JQM34_RS06885 (JQM34_0001404) comE 1441441..1442193 (+) 753 WP_200370611.1 competence system response regulator transcription factor ComE Regulator
  JQM34_RS06900 (JQM34_0001407) - 1442431..1442973 (-) 543 WP_000665080.1 TetR-like C-terminal domain-containing protein -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 41986.74 Da        Isoelectric Point: 6.3580

>NTDB_id=534544 JQM34_RS06860 WP_000681800.1 1437836..1439032(-) (htrA) [Streptococcus oralis strain SF100]
MKHLQKFYKKGVKVLAIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADDTNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSSDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=534544 JQM34_RS06860 WP_000681800.1 1437836..1439032(-) (htrA) [Streptococcus oralis strain SF100]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAGCAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTGCAACTTTATCAAAAACAAGGAAATCAAGCTACGAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAAAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGACGACACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATCCGCTTAGCAGATGGTACTAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCCGAAAAAGTTACAACAGTCGCAGAATTTGGAGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATTGGTAGTCCTTTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGGATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTC
CAGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGATGACAAAGAGATTGCCTCATCAACAGACCTACAACATGCTCTTTACAATCATGCTATCGGAGATACTATCAAAG
TAACCTACTACCGTAACGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTAGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)

Peptidase family M50 (Peptidase_M50)

(202-393)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9IBN0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.417

100

0.834
  htrA Streptococcus pneumoniae Rx1

82.663

100

0.827
  htrA Streptococcus pneumoniae D39

82.663

100

0.827
  htrA Streptococcus pneumoniae R6

82.663

100

0.827
  htrA Streptococcus pneumoniae TIGR4

82.663

100

0.827
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.673
  htrA Streptococcus mutans UA159

54.315

98.995

0.538