NTDB

Overview

Name	covR	Type	Regulator
Locus tag	LLUC047_RS08870	Genome accession	NZ_CP068658
Coordinates	1715492..1716184 (-)	Length	230 a.a.
NCBI ID	WP_011676631.1	Uniprot ID	A0A0M2ZTN8
Organism	Lactococcus cremoris strain UC047
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1710492..1721184

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC047_RS08850 (LLUC047_08620)	murD	1710636..1711985 (-)	1350	WP_021211936.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLUC047_RS08855 (LLUC047_08625)	-	1712154..1712495 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLUC047_RS08860 (LLUC047_08630)	-	1712580..1713821 (-)	1242	WP_021211937.1	ammonium transporter	-
LLUC047_RS08865 (LLUC047_08635)	covS	1714007..1715479 (-)	1473	WP_021215737.1	HAMP domain-containing histidine kinase	Regulator
LLUC047_RS08870 (LLUC047_08640)	covR	1715492..1716184 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLUC047_RS08875 (LLUC047_08645)	-	1716340..1716870 (-)	531	WP_205536385.1	DUF177 domain-containing protein	-
LLUC047_RS08880 (LLUC047_08650)	-	1717003..1717248 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLUC047_RS08885 (LLUC047_08655)	-	1717572..1717934 (-)	363	Protein_1728	TIGR02328 family protein	-
LLUC047_RS08890 (LLUC047_08660)	-	1718171..1719082 (-)	912	Protein_1729	CHAP domain-containing protein	-
LLUC047_RS08895 (LLUC047_08665)	-	1719175..1720032 (-)	858	WP_301004838.1	metallophosphoesterase	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26654.33 Da Isoelectric Point: 5.1273

                                >NTDB_id=530260 LLUC047_RS08870 WP_011676631.1 1715492..1716184(-) (covR) [Lactococcus cremoris strain UC047]

MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=530260 LLUC047_RS08870 WP_011676631.1 1715492..1716184(-) (covR) [Lactococcus cremoris strain UC047]

ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG

CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG

ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT

TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT

CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA

TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA

GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361

Detailed information NTG0530260