Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   LLUC047_RS08865 Genome accession   NZ_CP068658
Coordinates   1714007..1715479 (-) Length   490 a.a.
NCBI ID   WP_021215737.1    Uniprot ID   A0A896TBI1
Organism   Lactococcus cremoris strain UC047     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1707105..1753907 1714007..1715479 within 0


Gene organization within MGE regions


Location: 1707105..1753907
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LLUC047_RS08840 (LLUC047_08610) - 1708153..1709319 (-) 1167 WP_021215735.1 cell division protein FtsQ/DivIB -
  LLUC047_RS08845 (LLUC047_08615) murG 1709320..1710393 (-) 1074 WP_021215736.1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase -
  LLUC047_RS08850 (LLUC047_08620) murD 1710636..1711985 (-) 1350 WP_021211936.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -
  LLUC047_RS08855 (LLUC047_08625) - 1712154..1712495 (-) 342 WP_011676628.1 P-II family nitrogen regulator -
  LLUC047_RS08860 (LLUC047_08630) - 1712580..1713821 (-) 1242 WP_021211937.1 ammonium transporter -
  LLUC047_RS08865 (LLUC047_08635) covS 1714007..1715479 (-) 1473 WP_021215737.1 HAMP domain-containing histidine kinase Regulator
  LLUC047_RS08870 (LLUC047_08640) covR 1715492..1716184 (-) 693 WP_011676631.1 response regulator transcription factor Regulator
  LLUC047_RS08875 (LLUC047_08645) - 1716340..1716870 (-) 531 WP_205536385.1 DUF177 domain-containing protein -
  LLUC047_RS08880 (LLUC047_08650) - 1717003..1717248 (-) 246 WP_011676633.1 type B 50S ribosomal protein L31 -
  LLUC047_RS08885 (LLUC047_08655) - 1717572..1717934 (-) 363 Protein_1728 TIGR02328 family protein -
  LLUC047_RS08890 (LLUC047_08660) - 1718171..1719082 (-) 912 Protein_1729 CHAP domain-containing protein -
  LLUC047_RS08895 (LLUC047_08665) - 1719175..1720032 (-) 858 WP_301004838.1 metallophosphoesterase -
  LLUC047_RS08900 (LLUC047_08670) istA 1720100..1721323 (+) 1224 WP_003331415.1 IS21-like element IS712 family transposase -
  LLUC047_RS08905 (LLUC047_08675) istB 1721335..1722093 (+) 759 WP_003331414.1 IS21-like element IS712 family helper ATPase IstB -
  LLUC047_RS08910 (LLUC047_08680) - 1722182..1722382 (-) 201 Protein_1733 hypothetical protein -
  LLUC047_RS08915 (LLUC047_08685) - 1722486..1722728 (-) 243 WP_021215742.1 hypothetical protein -
  LLUC047_RS08920 (LLUC047_08690) - 1722730..1722930 (-) 201 WP_003132896.1 helix-turn-helix transcriptional regulator -
  LLUC047_RS08925 (LLUC047_08695) - 1723097..1723324 (+) 228 WP_057720732.1 DUF2188 domain-containing protein -
  LLUC047_RS08930 (LLUC047_08700) - 1723291..1723464 (-) 174 WP_205536386.1 hypothetical protein -
  LLUC047_RS08935 (LLUC047_08705) - 1723619..1723957 (-) 339 WP_021214422.1 hypothetical protein -
  LLUC047_RS08940 (LLUC047_08710) - 1723971..1724693 (-) 723 WP_205536387.1 ORF6N domain-containing protein -
  LLUC047_RS08945 (LLUC047_08715) - 1724708..1724938 (-) 231 WP_205536388.1 hypothetical protein -
  LLUC047_RS08950 (LLUC047_08720) - 1725228..1725575 (+) 348 WP_031288643.1 XRE family transcriptional regulator -
  LLUC047_RS08955 (LLUC047_08725) - 1725604..1726170 (+) 567 WP_021215745.1 hypothetical protein -
  LLUC047_RS13710 - 1726182..1726379 (+) 198 Protein_1743 hypothetical protein -
  LLUC047_RS08960 (LLUC047_14200) - 1726431..1727321 (+) 891 WP_373466553.1 SAP domain-containing protein -
  LLUC047_RS08965 (LLUC047_08735) - 1727435..1728574 (+) 1140 WP_021215747.1 site-specific integrase -
  LLUC047_RS08970 (LLUC047_08740) - 1728679..1729752 (-) 1074 WP_021215748.1 carbamoyl phosphate synthase small subunit -
  LLUC047_RS08975 (LLUC047_08745) - 1729840..1730772 (-) 933 WP_011676640.1 aspartate carbamoyltransferase catalytic subunit -
  LLUC047_RS08980 (LLUC047_08750) - 1731021..1732313 (-) 1293 WP_011834850.1 uracil-xanthine permease family protein -
  LLUC047_RS08985 (LLUC047_08755) pyrR 1732413..1732934 (-) 522 WP_011676642.1 bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR -
  LLUC047_RS08990 (LLUC047_08760) - 1733210..1733908 (-) 699 WP_015082648.1 M50 family metallopeptidase -
  LLUC047_RS08995 (LLUC047_08765) - 1734013..1734312 (+) 300 WP_011676644.1 helix-turn-helix transcriptional regulator -
  LLUC047_RS09000 (LLUC047_08770) - 1734302..1735219 (+) 918 WP_021037569.1 cation diffusion facilitator family transporter -
  LLUC047_RS09005 (LLUC047_08775) - 1735457..1736698 (-) 1242 WP_021215749.1 glutamate-5-semialdehyde dehydrogenase -
  LLUC047_RS09010 (LLUC047_08780) proB 1736809..1737615 (-) 807 WP_011834845.1 glutamate 5-kinase -
  LLUC047_RS09015 (LLUC047_08785) - 1737787..1739232 (-) 1446 WP_134794187.1 DUF438 domain-containing protein -
  LLUC047_RS09020 (LLUC047_08790) - 1739229..1739471 (-) 243 WP_015082654.1 DUF1858 domain-containing protein -
  LLUC047_RS09025 (LLUC047_08795) - 1739587..1739913 (-) 327 WP_015082655.1 AzlD domain-containing protein -
  LLUC047_RS09030 (LLUC047_08800) - 1739900..1740607 (-) 708 WP_021215750.1 AzlC family ABC transporter permease -
  LLUC047_RS09035 (LLUC047_08805) - 1740718..1741829 (+) 1112 WP_088792927.1 IS3-like element IS981 family transposase -
  LLUC047_RS09040 (LLUC047_08810) - 1742060..1742635 (+) 576 WP_126354783.1 NADPH-dependent F420 reductase -
  LLUC047_RS09045 (LLUC047_08815) - 1742720..1743262 (+) 543 WP_021215752.1 GNAT family N-acetyltransferase -
  LLUC047_RS09050 (LLUC047_08820) ffh 1743295..1744851 (-) 1557 WP_205536390.1 signal recognition particle protein -
  LLUC047_RS09055 (LLUC047_08825) - 1744930..1747986 (-) 3057 WP_021215754.1 leucine-rich repeat domain-containing protein -
  LLUC047_RS09060 (LLUC047_08830) - 1748045..1749748 (-) 1704 WP_205536391.1 ribonuclease J -
  LLUC047_RS09065 (LLUC047_08835) - 1750098..1750769 (+) 672 WP_021215756.1 MgtC/SapB family protein -
  LLUC047_RS09070 (LLUC047_08840) - 1750892..1751782 (+) 891 WP_301004839.1 IS982-like element IS982B family transposase -
  LLUC047_RS09075 (LLUC047_08845) dapA 1751815..1752708 (-) 894 WP_011676659.1 4-hydroxy-tetrahydrodipicolinate synthase -
  LLUC047_RS09080 (LLUC047_08850) - 1753037..1753492 (-) 456 WP_011676660.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 490 a.a.        Molecular weight: 55861.67 Da        Isoelectric Point: 4.7018

>NTDB_id=530259 LLUC047_RS08865 WP_021215737.1 1714007..1715479(-) (covS) [Lactococcus cremoris strain UC047]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQRLLTGSMDSVEEVLEQADAPL
NSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRRDFGFQKQGNNEMKEIQGENPGYLVQRKIV
SKGTGQVVGYLQAFYDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTNDFKPIEI
ESGDEIEELAHVYNDMMLKTKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVSNHALKNFQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNAVKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGIAEEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVSSELGIG
STFTLKFPKI

Nucleotide


Download         Length: 1473 bp        

>NTDB_id=530259 LLUC047_RS08865 WP_021215737.1 1714007..1715479(-) (covS) [Lactococcus cremoris strain UC047]
ATGAAAAAATTATTCACTTTCAACAAGAAAAAGGAAACGGTAGAAGAAAGTTCGGCTAAGCGGTCTATTATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTCTTTTTGCAACATTAACTTATCAACTGACCATAAGTTCTT
TCATCAAGGAGGAACAAAGGTTATTGACAGGTTCAATGGACAGCGTTGAAGAGGTATTAGAACAAGCGGATGCTCCTTTA
AATTCAACTAATTTGAATACGTATATTGAAGCGACATCAAAGATTCAAAATGGGGAATCGGAAGGAATGAGTCTGGGAAG
TATCATCGGGACTCGGAAAGCATTTTATATTTATGATTTAAATCATAAATTACTATATTCAACTAATCGACGTGATTTTG
GATTTCAAAAGCAAGGCAATAATGAGATGAAAGAAATTCAAGGTGAGAATCCAGGTTATTTAGTCCAAAGGAAGATTGTT
TCTAAAGGGACGGGACAGGTTGTAGGCTATTTACAGGCATTTTATGACACGACAACTTATCATCGGATTTCCAATCTCCT
TTTAGTCGTCTTGTTAATTTTAGAAATTGTCGCTTTAATCGTTGCGCAAATGATTGGTTATTTTATGGCGAATTATTTTA
TGAAGCCTTTAGAAAAACTTTATCAGGGAATGCAGGAAATGGCGAGCGACCCCACGAATGATTTCAAACCTATCGAAATT
GAAAGTGGTGATGAAATTGAAGAATTAGCTCATGTTTATAATGATATGATGCTGAAAACGAAAGCATACCTTGAACAGCA
AAATCGGTTTGTCTCTGATGTTTCACATGAATTAAGGACTCCGTTAGCAGTTTTGGACGGTCATATTAATCTCTTAAATC
GTTGGGGAAAAAATGATCCAGAAGTTTTGGATGAATCTTTGCAGGCGAGTTTGGATGAAGTAGACCGAATGAAGAAAATG
CTTGAAGAAATGCTTGCTTTGGCTAGGCTTGAAAATGTAGATTTGTCCAGTGAAGAATTGGATTGTGACGTTGGGAAAGT
ATCTAATCATGCGCTTAAAAACTTCCAACTTCTACATGAGGATTTTGAGATTGTACTTGATAATCAGCTTATCTACCCTG
TCCATGCCCGGATATCTGAAAATCATTTTGAACAAGGATTACGCATTTTGTTAGATAATGCTGTTAAGTATTCTCCGGAT
GATCGAAAGGAGATTGTGATTACTGTTTCAGAAGATGAACAGTTTGTCATTACTAGTGTTTCTGATAAAGGAATCGGAAT
TGCCGAAGAAGATATTAATCATCTTTTTGAGCGATTCTTTCGAGCGGATAAGGCACGTAACCGTGAGATTGGCGGAACTG
GTTTAGGTTTACCAATTCTGGCTCGTTTAGCCGAAAATTATCAAGGAGAGATTGAAGTTAGTTCTGAGCTTGGGATTGGT
TCAACTTTTACCTTAAAATTTCCAAAAATATGA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(267-332)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(380-488)

HAMP domain (HAMP)

(208-257)

ArlS sensor domain (ArlS_N)

(54-185)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Lactococcus lactis subsp. lactis strain DGCC12653

94.49

100

0.945