Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   I6J12_RS09195 Genome accession   NZ_CP068060
Coordinates   1922035..1923303 (-) Length   422 a.a.
NCBI ID   WP_003038347.1    Uniprot ID   I0S7M7
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1917879..1937774 1922035..1923303 within 0


Gene organization within MGE regions


Location: 1917879..1937774
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS09160 (I6J12_09160) - 1917879..1918190 (-) 312 WP_003027765.1 DUF1292 domain-containing protein -
  I6J12_RS09165 (I6J12_09165) ruvX 1918208..1918627 (-) 420 WP_003038407.1 Holliday junction resolvase RuvX -
  I6J12_RS09170 (I6J12_09170) - 1918627..1918893 (-) 267 WP_009569646.1 IreB family regulatory phosphoprotein -
  I6J12_RS09175 (I6J12_09175) - 1919174..1919665 (-) 492 WP_025271567.1 SP0191 family lipoprotein -
  I6J12_RS09180 (I6J12_09180) - 1919769..1920221 (-) 453 WP_003038334.1 SP0191 family lipoprotein -
  I6J12_RS11650 - 1920191..1920271 (-) 81 WP_229031567.1 lipoprotein -
  I6J12_RS09185 (I6J12_09185) spx 1920357..1920755 (-) 399 WP_003026638.1 transcriptional regulator Spx -
  I6J12_RS09190 (I6J12_09190) recA 1920842..1921987 (-) 1146 WP_003038330.1 recombinase RecA Machinery gene
  I6J12_RS09195 (I6J12_09195) cinA 1922035..1923303 (-) 1269 WP_003038347.1 competence/damage-inducible protein A Machinery gene
  I6J12_RS09200 (I6J12_09200) - 1923901..1924314 (+) 414 WP_195190250.1 EamA family transporter -
  I6J12_RS09205 (I6J12_09205) - 1924423..1924995 (-) 573 WP_003038379.1 DNA-3-methyladenine glycosylase I -
  I6J12_RS09210 (I6J12_09210) ruvA 1925006..1925596 (-) 591 WP_003038332.1 Holliday junction branch migration protein RuvA -
  I6J12_RS09215 (I6J12_09215) - 1925695..1926033 (+) 339 WP_003038373.1 hypothetical protein -
  I6J12_RS09220 (I6J12_09220) mutL 1926508..1928454 (-) 1947 WP_020999879.1 DNA mismatch repair endonuclease MutL -
  I6J12_RS09225 (I6J12_09225) - 1928549..1929697 (-) 1149 WP_003038317.1 tyrosine-type recombinase/integrase -
  I6J12_RS09230 (I6J12_09230) - 1929854..1930858 (-) 1005 WP_003038394.1 virulence RhuM family protein -
  I6J12_RS09235 (I6J12_09235) - 1931003..1931479 (-) 477 WP_003038410.1 helix-turn-helix domain-containing protein -
  I6J12_RS09240 (I6J12_09240) - 1931641..1931838 (+) 198 WP_003038356.1 helix-turn-helix domain-containing protein -
  I6J12_RS09245 (I6J12_09245) - 1931855..1932472 (+) 618 WP_003038403.1 Rha family transcriptional regulator -
  I6J12_RS09250 (I6J12_09250) - 1932476..1932643 (+) 168 WP_003038324.1 hypothetical protein -
  I6J12_RS09255 (I6J12_09255) - 1932986..1933264 (+) 279 WP_003027794.1 hypothetical protein -
  I6J12_RS09260 (I6J12_09260) - 1933261..1933437 (+) 177 WP_003027795.1 hypothetical protein -
  I6J12_RS09265 (I6J12_09265) - 1933427..1933663 (+) 237 WP_003038392.1 hypothetical protein -
  I6J12_RS09270 (I6J12_09270) - 1933660..1933995 (+) 336 WP_003038362.1 hypothetical protein -
  I6J12_RS09275 (I6J12_09275) - 1933997..1934266 (+) 270 WP_003038376.1 hypothetical protein -
  I6J12_RS09280 (I6J12_09280) - 1934275..1935081 (+) 807 WP_003038339.1 phage replisome organizer N-terminal domain-containing protein -
  I6J12_RS09285 (I6J12_09285) - 1935096..1935947 (+) 852 Protein_1849 ATP-binding protein -
  I6J12_RS09290 (I6J12_09290) - 1936196..1936636 (+) 441 WP_003038422.1 ArpU family phage packaging/lysis transcriptional regulator -
  I6J12_RS11470 - 1936918..1937031 (+) 114 Protein_1851 phage terminase small subunit P27 family -
  I6J12_RS09295 (I6J12_09295) - 1937167..1937358 (+) 192 WP_003038349.1 type II toxin-antitoxin system HicA family toxin -
  I6J12_RS09300 (I6J12_09300) - 1937394..1937774 (+) 381 WP_003038371.1 type II toxin-antitoxin system HicB family antitoxin -

Sequence

Protein


Download         Length: 422 a.a.        Molecular weight: 45465.12 Da        Isoelectric Point: 6.6664

>NTDB_id=526816 I6J12_RS09195 WP_003038347.1 1922035..1923303(-) (cinA) [Streptococcus anginosus strain FDAARGOS_1155]
MKAEIIAVGTEILTGQIVNTNARFLSEKLASLGVDVYFQTAVGDNEARLLSILEIARNRSNLVILTGGLGPTEDDLTKQT
LAKFLNRRLVFDRMATEKLDRFFASRPDYARTPNNERQAQIVEGSTPLQNETGLAVGGVIGVGGVTYVVLPGPPSELKPM
VNNELVPLLATGQKLYSRVLRFFGIGESQLVTLLGDLIDAQIDPTIAPYAKTGEVTLRLSTKAGSQKEADVKFAHLEKKI
LAVQTFEKQHLADLFYAYGDDSSLGQTAFELLIRAGKTVTAAESLTAGLFQATLANFAGASNVFSGGFVTYSMEEKSRML
GIPLADLEKHGVVSAFTAEKMAEQARKLTASDYAVSLTGVAGPDSLEGHPAGTVYIGLATTEDVQSIKVNIAGRSRTDVR
KIAVLHAFNLLRKTLLKNENML

Nucleotide


Download         Length: 1269 bp        

>NTDB_id=526816 I6J12_RS09195 WP_003038347.1 1922035..1923303(-) (cinA) [Streptococcus anginosus strain FDAARGOS_1155]
ATGAAAGCAGAAATTATTGCTGTGGGTACTGAAATTCTGACAGGTCAGATTGTCAATACAAATGCCCGATTTTTATCGGA
AAAATTAGCGAGTCTGGGTGTAGATGTGTATTTCCAAACAGCGGTTGGAGATAATGAAGCTCGTCTGTTATCCATTTTAG
AAATTGCTCGAAATCGTAGTAATTTGGTCATCTTAACTGGAGGATTAGGCCCAACAGAAGATGACTTGACTAAGCAGACT
TTGGCAAAATTCTTAAATCGTAGGTTGGTATTTGACCGAATGGCTACGGAGAAATTGGACCGCTTTTTCGCAAGTCGACC
GGATTATGCTCGAACACCAAACAATGAGCGGCAAGCTCAGATAGTGGAAGGCTCGACTCCTCTCCAAAACGAAACCGGAC
TTGCGGTGGGAGGCGTGATTGGAGTCGGCGGCGTGACTTATGTTGTTCTCCCCGGACCGCCTAGTGAATTAAAGCCTATG
GTAAATAATGAGCTAGTTCCGCTTTTAGCGACTGGTCAAAAATTGTATTCAAGAGTCTTGCGATTCTTTGGTATCGGTGA
AAGTCAATTAGTAACTCTTTTAGGAGATTTAATTGATGCTCAGATCGATCCGACCATTGCTCCTTATGCTAAGACGGGAG
AGGTGACATTGCGATTGTCCACAAAGGCTGGCAGTCAAAAGGAAGCAGATGTTAAGTTTGCTCATTTAGAAAAGAAAATT
TTGGCAGTACAGACTTTTGAGAAACAACATTTAGCAGACCTTTTCTACGCTTATGGAGATGATAGTTCTCTGGGACAAAC
AGCTTTTGAACTGCTGATAAGAGCAGGAAAGACCGTCACAGCAGCTGAAAGTTTGACTGCAGGACTCTTTCAAGCAACTT
TGGCAAACTTTGCTGGAGCCTCCAATGTTTTTAGTGGTGGCTTTGTTACCTACAGTATGGAGGAAAAGAGCCGAATGCTG
GGCATTCCCTTGGCAGACTTAGAAAAGCATGGGGTAGTTTCAGCTTTTACAGCGGAGAAAATGGCTGAGCAGGCAAGAAA
ATTGACCGCTAGTGACTATGCGGTGAGCTTGACAGGTGTGGCAGGTCCAGACAGCTTAGAAGGACATCCAGCAGGGACAG
TTTATATCGGCTTAGCAACTACAGAGGATGTTCAGTCTATTAAGGTTAATATTGCGGGTCGCAGTCGGACAGATGTACGT
AAAATAGCCGTTCTGCATGCTTTCAATCTGCTACGAAAAACTTTATTAAAAAACGAAAATATGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-415)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S7M7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

76.077

99.052

0.754
  cinA Streptococcus pneumoniae TIGR4

75.359

99.052

0.746
  cinA Streptococcus pneumoniae Rx1

75.359

99.052

0.746
  cinA Streptococcus pneumoniae R6

75.359

99.052

0.746
  cinA Streptococcus mitis NCTC 12261

75.12

99.052

0.744
  cinA Streptococcus pneumoniae D39

75.12

99.052

0.744
  cinA Streptococcus mutans UA159

72.104

100

0.723
  cinA Streptococcus suis isolate S10

55.048

98.578

0.543
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

99.052

0.45