Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   JHX98_RS09140 Genome accession   NZ_CP067010
Coordinates   1813513..1814784 (-) Length   423 a.a.
NCBI ID   WP_011018313.1    Uniprot ID   A2RGU9
Organism   Streptococcus pyogenes strain iGAS376     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1808513..1819784
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JHX98_RS09115 (JHX98_09115) - 1810484..1810789 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  JHX98_RS09120 (JHX98_09120) ruvX 1810801..1811220 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  JHX98_RS09125 (JHX98_09125) - 1811217..1811486 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  JHX98_RS09130 (JHX98_09130) spx 1811599..1811997 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  JHX98_RS09135 (JHX98_09135) recA 1812288..1813424 (-) 1137 WP_002982186.1 recombinase RecA Machinery gene
  JHX98_RS09140 (JHX98_09140) cinA 1813513..1814784 (-) 1272 WP_011018313.1 competence/damage-inducible protein A Machinery gene
  JHX98_RS09145 (JHX98_09145) - 1814853..1815413 (-) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  JHX98_RS09150 (JHX98_09150) ruvA 1815423..1816019 (-) 597 WP_011185063.1 Holliday junction branch migration protein RuvA -
  JHX98_RS09155 (JHX98_09155) - 1816021..1817241 (-) 1221 WP_023077191.1 MFS transporter -
  JHX98_RS09160 (JHX98_09160) mutL 1817252..1819234 (-) 1983 WP_011889221.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45908.59 Da        Isoelectric Point: 4.7648

>NTDB_id=524363 JHX98_RS09140 WP_011018313.1 1813513..1814784(-) (cinA) [Streptococcus pyogenes strain iGAS376]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKSM
VNEELVPLLSKQYSTLYSKVLRFFGVGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGQSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=524363 JHX98_RS09140 WP_011018313.1 1813513..1814784(-) (cinA) [Streptococcus pyogenes strain iGAS376]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGTCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTGTTGG
GGAAAGTCAGTTGGTAACAGTTTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCAAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RGU9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

68.794

100

0.688
  cinA Streptococcus mitis SK321

69.065

98.582

0.681
  cinA Streptococcus mitis NCTC 12261

68.585

98.582

0.676
  cinA Streptococcus pneumoniae TIGR4

67.626

98.582

0.667
  cinA Streptococcus pneumoniae Rx1

67.626

98.582

0.667
  cinA Streptococcus pneumoniae R6

67.626

98.582

0.667
  cinA Streptococcus pneumoniae D39

67.386

98.582

0.664
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456