Detailed information NTG0520712

Bioinformatically predicted

Overview

• Name: cinA
• Type: Machinery gene
• Locus tag: JF649_RS08490
• Genome accession: NZ_CP066541
• Coordinates: 1726818..1728089 (-)
• Length: 423 a.a.
• NCBI ID: WP_129322339.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS270
• Function: require for competence (predicted from homology) Unclear

Genomic Context

Location: 1721818..1733089

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JF649_RS08460 (JF649_08445)	-	1721818..1723377 (-)	1560	WP_030126183.1	membrane protein	-
JF649_RS08465 (JF649_08450)	-	1723789..1724094 (-)	306	WP_002982199.1	DUF1292 domain-containing protein	-
JF649_RS08470 (JF649_08455)	ruvX	1724106..1724525 (-)	420	WP_002982196.1	Holliday junction resolvase RuvX	-
JF649_RS08475 (JF649_08460)	-	1724522..1724791 (-)	270	WP_002982194.1	IreB family regulatory phosphoprotein	-
JF649_RS08480 (JF649_08465)	spx	1724904..1725302 (-)	399	WP_002982188.1	transcriptional regulator Spx	-
JF649_RS08485 (JF649_08470)	recA	1725593..1726729 (-)	1137	WP_002992179.1	recombinase RecA	Machinery gene
JF649_RS08490 (JF649_08475)	cinA	1726818..1728089 (-)	1272	WP_129322339.1	competence/damage-inducible protein A	Machinery gene
JF649_RS08495 (JF649_08480)	-	1728158..1728718 (-)	561	WP_136069689.1	DNA-3-methyladenine glycosylase I	-
JF649_RS08500 (JF649_08485)	ruvA	1728728..1729324 (-)	597	WP_011285268.1	Holliday junction branch migration protein RuvA	-
JF649_RS08505 (JF649_08490)	-	1729326..1730546 (-)	1221	WP_002991361.1	MFS transporter	-
JF649_RS08510 (JF649_08495)	mutL	1730557..1732539 (-)	1983	WP_129322343.1	DNA mismatch repair endonuclease MutL	-

Sequence

Protein

• Length: 423 a.a.
• Molecular weight: 45973.71 Da
• Isoelectric Point: 4.9060

>NTDB_id=520712 JF649_RS08490 WP_129322339.1 1726818..1728089(-) (cinA) [Streptococcus pyogenes strain MGAS270]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASHRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLAGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKIESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide

• Length: 1272 bp

>NTDB_id=520712 JF649_RS08490 WP_129322339.1 1726818..1728089(-) (cinA) [Streptococcus pyogenes strain MGAS270]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCATCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GCTATTGGCTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGATAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

• Probable molybdopterin binding domain (MoCF_biosynth) (5-170)

• Damage-inducible protein CinA KH domain (CinA_KH) (178-243)

• Competence-damaged protein (CinA) (263-416)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cinA	Streptococcus mutans UA159	69.267	100	0.693
cinA	Streptococcus mitis SK321	69.305	98.582	0.683
cinA	Streptococcus mitis NCTC 12261	68.825	98.582	0.678
cinA	Streptococcus pneumoniae TIGR4	67.866	98.582	0.669
cinA	Streptococcus pneumoniae Rx1	67.866	98.582	0.669
cinA	Streptococcus pneumoniae R6	67.866	98.582	0.669
cinA	Streptococcus pneumoniae D39	67.626	98.582	0.667
cinA	Streptococcus suis isolate S10	53.365	98.345	0.525
cinA	Bacillus subtilis subsp. subtilis str. 168	46.411	98.818	0.459