NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	I6H78_RS01795	Genome accession	NZ_CP066059
Coordinates	377734..378384 (-)	Length	216 a.a.
NCBI ID	WP_198459755.1	Uniprot ID	A0A7T4M0V4
Organism	Streptococcus oralis strain FDAARGOS_1021
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 372734..383384

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H78_RS01775 (I6H78_01775)	-	373325..374509 (-)	1185	WP_198459751.1	hypothetical protein	-
I6H78_RS01780 (I6H78_01780)	-	374513..375100 (-)	588	WP_198459752.1	ATP-binding cassette domain-containing protein	-
I6H78_RS01785 (I6H78_01785)	-	375133..375321 (-)	189	WP_061419442.1	hypothetical protein	-
I6H78_RS01790 (I6H78_01790)	comEC/celB	375510..377750 (-)	2241	WP_198459754.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
I6H78_RS01795 (I6H78_01795)	comEA/celA/cilE	377734..378384 (-)	651	WP_198459755.1	helix-hairpin-helix domain-containing protein	Machinery gene
I6H78_RS01800 (I6H78_01800)	-	378451..379020 (-)	570	WP_198459756.1	GNAT family N-acetyltransferase	-
I6H78_RS01805 (I6H78_01805)	ald	379197..380309 (+)	1113	WP_198459757.1	alanine dehydrogenase	-
I6H78_RS01810 (I6H78_01810)	tnpA	380469..380932 (-)	464	Protein_360	IS200/IS605 family transposase	-
I6H78_RS01815 (I6H78_01815)	-	381122..382108 (-)	987	WP_125425819.1	PhoH family protein	-
I6H78_RS01820 (I6H78_01820)	-	382189..382404 (-)	216	WP_198459758.1	YozE family protein	-
I6H78_RS01825 (I6H78_01825)	-	382417..383007 (-)	591	WP_198459759.1	GrpB family protein	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23234.42 Da Isoelectric Point: 5.9270

                                >NTDB_id=516934 I6H78_RS01795 WP_198459755.1 377734..378384(-) (comEA/celA/cilE) [Streptococcus oralis strain FDAARGOS_1021]

MEAIIEKIKEYKIIVICACLGLALGGFFLLKPSSQTSVKETNLQAEVAAVSKDSSSEKEVKKEEKEESPEQDLITVDVKG

AVKSPGIYDLPVGSRVHDAVQKAGGLTEEADSKSLNLAQKVSDEALVYVQTKGEESASQQVASGTTPSTSKEKKVNLNKA

SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=516934 I6H78_RS01795 WP_198459755.1 377734..378384(-) (comEA/celA/cilE) [Streptococcus oralis strain FDAARGOS_1021]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTCATCTGTGCTTGTTTGGGTCTGGCCTTAGGTGGCTT

TTTCCTGCTAAAGCCAAGTTCACAAACATCTGTGAAAGAAACGAATTTGCAGGCTGAAGTTGCAGCCGTTTCAAAGGATT

CATCGTCTGAAAAAGAAGTGAAGAAGGAGGAAAAAGAAGAATCTCCTGAACAAGATCTAATTACAGTGGATGTCAAAGGT

GCCGTTAAATCGCCAGGGATTTATGATTTGCCAGTAGGCAGTCGTGTTCATGATGCCGTTCAGAAAGCTGGTGGCTTGAC

AGAGGAGGCAGATAGTAAGTCGCTCAATCTCGCTCAGAAAGTCAGTGACGAGGCTCTTGTCTATGTTCAAACTAAGGGGG

AAGAATCAGCTAGTCAGCAGGTTGCCTCTGGAACGACTCCCTCGACAAGTAAAGAAAAGAAGGTCAACCTCAATAAAGCT

AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGTGGCAAACGAGCCCAGGATATTATTGATCATCGTGAGGCAAATGG

CAAATTCAAGTCGGTAGATGAATTAAAGAAAGTCTCTGGTATTGGCGCTAAGACCATAGAAAAGCTAAAAGATTATGTCA

CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-125)

Helix-hairpin-helix motif (HHH_3)

(151-214)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A7T4M0V4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	90.741	100	0.907
comEA/celA/cilE	Streptococcus mitis NCTC 12261	90.741	100	0.907
comEA/celA/cilE	Streptococcus pneumoniae Rx1	88.889	100	0.889
comEA/celA/cilE	Streptococcus pneumoniae D39	88.889	100	0.889
comEA/celA/cilE	Streptococcus pneumoniae R6	88.889	100	0.889
comEA/celA/cilE	Streptococcus mitis SK321	87.5	100	0.875
comEA	Lactococcus lactis subsp. cremoris KW2	41.41	100	0.435
comEA	Streptococcus thermophilus LMD-9	39.524	97.222	0.384

Detailed information NTG0516934