Detailed information NTG0513304

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: I6G42_RS05880
• Genome accession: NZ_CP065707
• Coordinates: 1204726..1205376 (+)
• Length: 216 a.a.
• NCBI ID: WP_038805079.1
• Uniprot ID: A0A7T2ZVA7
• Organism: Streptococcus oralis strain FDAARGOS_885
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1199726..1210376

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G42_RS05850 (I6G42_05850)	cvfB	1200001..1200855 (+)	855	WP_038805072.1	RNA-binding virulence regulatory protein CvfB	-
I6G42_RS05855 (I6G42_05855)	-	1200867..1201472 (+)	606	WP_038805073.1	GrpB family protein	-
I6G42_RS05860 (I6G42_05860)	-	1201469..1201684 (+)	216	WP_038805074.1	YozE family protein	-
I6G42_RS05865 (I6G42_05865)	-	1201765..1202751 (+)	987	WP_038805075.1	PhoH family protein	-
I6G42_RS05870 (I6G42_05870)	ald	1202801..1203913 (-)	1113	WP_038805076.1	alanine dehydrogenase	-
I6G42_RS05875 (I6G42_05875)	-	1204090..1204659 (+)	570	WP_038805078.1	GNAT family N-acetyltransferase	-
I6G42_RS05880 (I6G42_05880)	comEA/celA/cilE	1204726..1205376 (+)	651	WP_038805079.1	helix-hairpin-helix domain-containing protein	Machinery gene
I6G42_RS05885 (I6G42_05885)	comEC/celB	1205360..1207600 (+)	2241	WP_038805080.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
I6G42_RS05890 (I6G42_05890)	infC	1207820..1208350 (+)	531	WP_000848184.1	translation initiation factor IF-3	-
I6G42_RS05895 (I6G42_05895)	rpmI	1208383..1208583 (+)	201	WP_001125942.1	50S ribosomal protein L35	-
I6G42_RS05900 (I6G42_05900)	rplT	1208635..1208994 (+)	360	WP_000124830.1	50S ribosomal protein L20	-
I6G42_RS05905 (I6G42_05905)	-	1209053..1209433 (+)	381	WP_038805081.1	VOC family protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23179.42 Da
• Isoelectric Point: 5.9284

>NTDB_id=513304 I6G42_RS05880 WP_038805079.1 1204726..1205376(+) (comEA/celA/cilE) [Streptococcus oralis strain FDAARGOS_885]
MEVIIEKIKEYKIIVICAGLGLALGGFFLLKPTSQTPVKETNLQAEVAAVSKDSSSEKEVKKEEKEESPEQDLITVDVKG
AVKSPGIYDLPLGSRVHDAVQKAGGLTEEADSKSLNLAQKISDEALVYVPTKGEEAASQQAASGTSPSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=513304 I6G42_RS05880 WP_038805079.1 1204726..1205376(+) (comEA/celA/cilE) [Streptococcus oralis strain FDAARGOS_885]
ATGGAAGTCATTATCGAGAAAATCAAAGAATATAAAATCATTGTCATCTGTGCTGGCTTGGGTTTAGCCTTAGGCGGATT
TTTCCTGCTAAAGCCAACTTCACAAACACCTGTGAAAGAAACAAATTTGCAGGCTGAAGTTGCGGCCGTTTCAAAGGATT
CATCGTCTGAAAAGGAAGTCAAGAAGGAAGAAAAGGAAGAGTCTCCTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTCTTGGCAGTCGAGTTCACGATGCCGTTCAGAAGGCGGGTGGCTTGAC
AGAAGAAGCAGACAGCAAGTCGCTTAATCTAGCACAGAAAATCAGTGACGAGGCTCTTGTCTATGTTCCAACTAAGGGAG
AAGAAGCAGCTAGTCAGCAGGCTGCCTCTGGAACGTCTCCTTCGACAAGTAAAGAAAAGAAGGTCAACCTCAATAAAGCC
AGTCTGGAAGAACTCAAGCAGGTCAAAGGCTTGGGAGGAAAACGAGCACAGGATATTATCGACCATCGTGAGGCGAATGG
CAAATTCAAGTCGGTAGATGAATTAAAGAAAGTCTCTGGCATTGGCGCTAAGACCATAGAAAAGCTAAAAGATTATGTCA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-127)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A7T2ZVA7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	91.667	100	0.917
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	91.204	100	0.912
comEA/celA/cilE	Streptococcus pneumoniae D39	89.352	100	0.894
comEA/celA/cilE	Streptococcus pneumoniae R6	89.352	100	0.894
comEA/celA/cilE	Streptococcus pneumoniae Rx1	89.352	100	0.894
comEA/celA/cilE	Streptococcus mitis SK321	87.5	100	0.875
comEA	Lactococcus lactis subsp. cremoris KW2	40.991	100	0.421
comEA	Streptococcus thermophilus LMD-9	39.524	97.222	0.384
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361