Detailed information NTG0513217

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: I6G43_RS04420
• Genome accession: NZ_CP065706
• Coordinates: 932369..933019 (+)
• Length: 216 a.a.
• NCBI ID: WP_038805079.1
• Uniprot ID: A0A7T2ZVA7
• Organism: Streptococcus oralis strain FDAARGOS_886
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 927369..938019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G43_RS04390 (I6G43_04390)	cvfB	927632..928486 (+)	855	WP_001095457.1	RNA-binding virulence regulatory protein CvfB	-
I6G43_RS04395 (I6G43_04395)	-	928498..929076 (+)	579	WP_009014028.1	GrpB family protein	-
I6G43_RS04400 (I6G43_04400)	-	929100..929315 (+)	216	WP_001232084.1	YozE family protein	-
I6G43_RS04405 (I6G43_04405)	-	929396..930382 (+)	987	WP_000658176.1	PhoH family protein	-
I6G43_RS04410 (I6G43_04410)	ald	930444..931556 (-)	1113	WP_038806202.1	alanine dehydrogenase	-
I6G43_RS04415 (I6G43_04415)	-	931733..932302 (+)	570	WP_038805078.1	GNAT family N-acetyltransferase	-
I6G43_RS04420 (I6G43_04420)	comEA/celA/cilE	932369..933019 (+)	651	WP_038805079.1	helix-hairpin-helix domain-containing protein	Machinery gene
I6G43_RS04425 (I6G43_04425)	comEC/celB	933003..935243 (+)	2241	WP_038805080.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
I6G43_RS04430 (I6G43_04430)	infC	935463..935993 (+)	531	WP_000848184.1	translation initiation factor IF-3	-
I6G43_RS04435 (I6G43_04435)	rpmI	936026..936226 (+)	201	WP_001125942.1	50S ribosomal protein L35	-
I6G43_RS04440 (I6G43_04440)	rplT	936278..936637 (+)	360	WP_000124830.1	50S ribosomal protein L20	-
I6G43_RS04445 (I6G43_04445)	-	936696..937076 (+)	381	WP_038806201.1	VOC family protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23179.42 Da
• Isoelectric Point: 5.9284

>NTDB_id=513217 I6G43_RS04420 WP_038805079.1 932369..933019(+) (comEA/celA/cilE) [Streptococcus oralis strain FDAARGOS_886]
MEVIIEKIKEYKIIVICAGLGLALGGFFLLKPTSQTPVKETNLQAEVAAVSKDSSSEKEVKKEEKEESPEQDLITVDVKG
AVKSPGIYDLPLGSRVHDAVQKAGGLTEEADSKSLNLAQKISDEALVYVPTKGEEAASQQAASGTSPSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=513217 I6G43_RS04420 WP_038805079.1 932369..933019(+) (comEA/celA/cilE) [Streptococcus oralis strain FDAARGOS_886]
ATGGAAGTCATTATCGAGAAAATCAAAGAATATAAAATCATTGTCATCTGTGCTGGCTTGGGTTTAGCCTTAGGCGGATT
TTTCCTGCTAAAGCCAACTTCACAAACACCTGTGAAAGAAACAAATTTGCAGGCTGAAGTTGCGGCCGTTTCAAAGGATT
CATCGTCTGAAAAGGAAGTCAAGAAGGAAGAAAAGGAAGAGTCTCCTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTCTTGGCAGTCGAGTTCACGATGCCGTTCAGAAGGCGGGTGGCTTGAC
AGAAGAAGCAGACAGCAAGTCGCTTAATCTAGCACAGAAAATCAGTGACGAGGCTCTTGTCTATGTTCCAACTAAGGGAG
AAGAAGCAGCTAGTCAGCAGGCTGCCTCTGGAACGTCTCCTTCGACAAGTAAAGAAAAGAAGGTCAACCTCAATAAAGCC
AGTCTGGAAGAACTCAAGCAGGTCAAAGGCTTGGGAGGAAAACGAGCACAGGATATTATCGACCATCGTGAGGCGAATGG
CAAATTCAAGTCGGTAGATGAATTAAAGAAAGTCTCTGGCATTGGCGCTAAGACCATAGAAAAGCTAAAAGATTATGTCA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-127)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A7T2ZVA7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	91.667	100	0.917
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	91.204	100	0.912
comEA/celA/cilE	Streptococcus pneumoniae D39	89.352	100	0.894
comEA/celA/cilE	Streptococcus pneumoniae R6	89.352	100	0.894
comEA/celA/cilE	Streptococcus pneumoniae Rx1	89.352	100	0.894
comEA/celA/cilE	Streptococcus mitis SK321	87.5	100	0.875
comEA	Lactococcus lactis subsp. cremoris KW2	40.991	100	0.421
comEA	Streptococcus thermophilus LMD-9	39.524	97.222	0.384
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361