Detailed information NTG0513190

Bioinformatically predicted

Overview

• Name: comGA/cglA/cilD
• Type: Machinery gene
• Locus tag: I6G43_RS01760
• Genome accession: NZ_CP065706
• Coordinates: 363077..364018 (+)
• Length: 313 a.a.
• NCBI ID: WP_038805745.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain FDAARGOS_886
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	361958..362347	363077..364018	flank	730

Gene organization within MGE regions

Location: 361958..364018

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G43_RS01755 (I6G43_01755)	-	362646..363011 (+)	366	WP_038805747.1	DUF1033 family protein	-
I6G43_RS01760 (I6G43_01760)	comGA/cglA/cilD	363077..364018 (+)	942	WP_038805745.1	competence type IV pilus ATPase ComGA	Machinery gene

Sequence

Protein

• Length: 313 a.a.
• Molecular weight: 35443.46 Da
• Isoelectric Point: 5.8179

>NTDB_id=513190 I6G43_RS01760 WP_038805745.1 363077..364018(+) (comGA/cglA/cilD) [Streptococcus oralis strain FDAARGOS_886]
MVQEIAQKIIATAKEKGAQDIYFIPKEVTYELHMRIGDERCLVDSYEFEVLAAVISHFKFVAGMNVGEKRRSQLGSCDYQ
HGEKLSSLRLSTVGDYRGHESLVIRLLHDEERELRFWFQDLAKLGEQYRQRGLYLFAGPVGSGKTTLMHELAKSLFKGQQ
VMSIEDPVEIKQEDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVTEEELAVVLQGVCYQRLIGGGGILDFANKNYQDHQPTSWNEQIDQLLKDGHITSLQAETEKIGYS

Nucleotide

• Length: 942 bp

>NTDB_id=513190 I6G43_RS01760 WP_038805745.1 363077..364018(+) (comGA/cglA/cilD) [Streptococcus oralis strain FDAARGOS_886]
ATGGTACAAGAAATTGCACAGAAAATTATTGCTACTGCTAAGGAAAAAGGAGCTCAGGATATCTATTTCATTCCCAAAGA
AGTTACTTATGAACTTCATATGCGAATTGGCGATGAGAGGTGTTTAGTTGACTCCTATGAATTTGAGGTTTTAGCAGCTG
TAATTAGTCACTTCAAGTTTGTGGCGGGTATGAATGTAGGAGAAAAACGCCGTAGTCAGCTGGGCTCTTGTGACTACCAG
CATGGGGAAAAGCTATCTTCTCTGCGTTTATCTACCGTAGGAGATTATCGGGGACATGAGAGCTTGGTCATTCGGTTGTT
GCACGATGAGGAAAGGGAGTTGCGATTTTGGTTTCAGGATTTAGCAAAATTGGGAGAACAATACAGGCAAAGGGGGCTCT
ACCTTTTTGCGGGTCCAGTCGGCAGTGGTAAGACGACCTTGATGCACGAATTAGCCAAGTCTCTTTTTAAGGGGCAGCAG
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGAAGACATGCTCCAGTTGCAGTTGAATGAGGCAATTGGATTGAC
CTATGAAAATCTGATCAAACTGTCTCTCCGACATCGTCCTGACCTCTTGATAATCGGTGAAATTCGGGACAGTGAGACGG
CGCGTGCAGTTGTCAGAGCCAGTTTGACAGGTGCGACGGTCTTTTCAACCATTCATGCCAAGAGTATCCGAGGTGTTTAT
GAGCGCCTTCTGGAGTTAGGTGTGACTGAGGAGGAACTAGCAGTTGTCTTACAAGGCGTCTGTTATCAGAGATTAATCGG
GGGAGGAGGAATCCTTGACTTTGCAAACAAAAACTATCAAGACCACCAGCCAACTAGCTGGAATGAGCAGATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAAACGGAAAAAATTGGCTACAGCTAA

Domains

Predicted by InterproScan.

• Type II/IV secretion system protein (T2SSE) (8-266)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGA/cglA/cilD	Streptococcus mitis NCTC 12261	87.54	100	0.875
comGA/cglA/cilD	Streptococcus pneumoniae Rx1	86.581	100	0.866
comGA/cglA/cilD	Streptococcus pneumoniae D39	86.581	100	0.866
comGA/cglA/cilD	Streptococcus pneumoniae R6	86.581	100	0.866
comGA/cglA/cilD	Streptococcus pneumoniae TIGR4	86.581	100	0.866
comYA	Streptococcus gordonii str. Challis substr. CH1	78.387	99.042	0.776
comYA	Streptococcus mutans UA159	64.952	99.361	0.645
comYA	Streptococcus mutans UA140	64.952	99.361	0.645
comGA/cglA	Streptococcus sobrinus strain NIDR 6715-7	61.613	99.042	0.61
comGA	Lactococcus lactis subsp. cremoris KW2	55.949	99.361	0.556
comGA	Latilactobacillus sakei subsp. sakei 23K	44.106	84.026	0.371