Detailed information NTG0511259

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: STT55_RS05595
• Genome accession: NZ_CP065502
• Coordinates: 1062962..1063669 (-)
• Length: 235 a.a.
• NCBI ID: WP_173940375.1
• Uniprot ID: A0A2H4K9R7
• Organism: Streptococcus thermophilus strain ST55
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1057962..1068669

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STT55_RS05570 (STT55_05525)	yidA	1058313..1059122 (+)	810	WP_011226081.1	sugar-phosphatase	-
STT55_RS05575 (STT55_05530)	-	1059124..1060338 (+)	1215	WP_173940373.1	aminoacyltransferase	-
STT55_RS05580 (STT55_05535)	-	1060390..1060751 (-)	362	Protein_1044	YbaN family protein	-
STT55_RS05585 (STT55_05540)	vicX	1060811..1061623 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
STT55_RS05590 (STT55_05545)	vicK	1061629..1062969 (-)	1341	WP_232979188.1	cell wall metabolism sensor histidine kinase VicK	Regulator
STT55_RS05595 (STT55_05550)	vicR	1062962..1063669 (-)	708	WP_173940375.1	response regulator YycF	Regulator
STT55_RS05600 (STT55_05555)	-	1064196..1064963 (+)	768	WP_173940376.1	amino acid ABC transporter ATP-binding protein	-
STT55_RS05605 (STT55_05560)	-	1064975..1065808 (+)	834	WP_022096756.1	transporter substrate-binding domain-containing protein	-
STT55_RS05610 (STT55_05565)	-	1065826..1066524 (+)	699	WP_022096755.1	amino acid ABC transporter permease	-
STT55_RS05615 (STT55_05570)	-	1066536..1067186 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
STT55_RS05620 (STT55_05575)	endA	1067258..1068139 (-)	882	WP_022096754.1	DNA/RNA non-specific endonuclease	Machinery gene
STT55_RS05625 (STT55_05580)	-	1068201..1068389 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27087.04 Da
• Isoelectric Point: 5.0130

>NTDB_id=511259 STT55_RS05595 WP_173940375.1 1062962..1063669(-) (vicR) [Streptococcus thermophilus strain ST55]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEIAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=511259 STT55_RS05595 WP_173940375.1 1062962..1063669(-) (vicR) [Streptococcus thermophilus strain ST55]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAATTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: A0A2H4K9R7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.106	100	0.851
micA	Streptococcus pneumoniae Cp1015	79.828	99.149	0.791
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.455	98.298	0.447
covR	Streptococcus salivarius strain HSISS4	44.872	99.574	0.447
scnR	Streptococcus mutans UA159	38.136	100	0.383