Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SPYALAB49_RS04620 Genome accession   NC_017596
Coordinates   920983..921657 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes Alab49     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 915983..926657
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS04595 (SPYALAB49_000934) - 916432..916821 (-) 390 WP_002984531.1 cytidine deaminase -
  SPYALAB49_RS04600 (SPYALAB49_000935) - 917472..918065 (-) 594 WP_002989699.1 class I SAM-dependent methyltransferase -
  SPYALAB49_RS04605 (SPYALAB49_000936) coaA 918333..919253 (+) 921 WP_002984525.1 type I pantothenate kinase -
  SPYALAB49_RS04610 (SPYALAB49_000937) rpsT 919307..919555 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  SPYALAB49_RS04615 (SPYALAB49_000938) ciaH 919680..920990 (-) 1311 WP_011054528.1 cell wall metabolism sensor histidine kinase WalK Regulator
  SPYALAB49_RS04620 (SPYALAB49_000939) ciaR 920983..921657 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  SPYALAB49_RS04625 (SPYALAB49_000940) - 922004..924541 (-) 2538 WP_014635484.1 M1 family metallopeptidase -
  SPYALAB49_RS04630 (SPYALAB49_000941) phoU 924746..925399 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  SPYALAB49_RS04635 (SPYALAB49_000942) pstB 925467..926225 (-) 759 WP_014635485.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=49536 SPYALAB49_RS04620 WP_002984519.1 920983..921657(-) (ciaR) [Streptococcus pyogenes Alab49]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=49536 SPYALAB49_RS04620 WP_002984519.1 920983..921657(-) (ciaR) [Streptococcus pyogenes Alab49]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment