Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SPYALAB49_RS04615 Genome accession   NC_017596
Coordinates   919680..920990 (-) Length   436 a.a.
NCBI ID   WP_011054528.1    Uniprot ID   A0A4U9BXV0
Organism   Streptococcus pyogenes Alab49     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 914680..925990
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS04590 (SPYALAB49_000933) - 915286..916338 (-) 1053 WP_014635483.1 BMP family protein -
  SPYALAB49_RS04595 (SPYALAB49_000934) - 916432..916821 (-) 390 WP_002984531.1 cytidine deaminase -
  SPYALAB49_RS04600 (SPYALAB49_000935) - 917472..918065 (-) 594 WP_002989699.1 class I SAM-dependent methyltransferase -
  SPYALAB49_RS04605 (SPYALAB49_000936) coaA 918333..919253 (+) 921 WP_002984525.1 type I pantothenate kinase -
  SPYALAB49_RS04610 (SPYALAB49_000937) rpsT 919307..919555 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  SPYALAB49_RS04615 (SPYALAB49_000938) ciaH 919680..920990 (-) 1311 WP_011054528.1 cell wall metabolism sensor histidine kinase WalK Regulator
  SPYALAB49_RS04620 (SPYALAB49_000939) ciaR 920983..921657 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  SPYALAB49_RS04625 (SPYALAB49_000940) - 922004..924541 (-) 2538 WP_014635484.1 M1 family metallopeptidase -
  SPYALAB49_RS04630 (SPYALAB49_000941) phoU 924746..925399 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 436 a.a.        Molecular weight: 50112.66 Da        Isoelectric Point: 9.2692

>NTDB_id=49535 SPYALAB49_RS04615 WP_011054528.1 919680..920990(-) (ciaH) [Streptococcus pyogenes Alab49]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide


Download         Length: 1311 bp        

>NTDB_id=49535 SPYALAB49_RS04615 WP_011054528.1 919680..920990(-) (ciaH) [Streptococcus pyogenes Alab49]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGATAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAACTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAATTATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(329-436)

His Kinase A (phospho-acceptor) domain (HisKA)

(220-285)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9BXV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

57.895

100

0.58
  ciaH Streptococcus pneumoniae Rx1

51.37

100

0.516
  ciaH Streptococcus pneumoniae D39

51.37

100

0.516
  ciaH Streptococcus pneumoniae R6

51.37

100

0.516
  ciaH Streptococcus pneumoniae TIGR4

51.37

100

0.516

Multiple sequence alignment