Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   SPYALAB49_RS00650 Genome accession   NC_017596
Coordinates   102160..103098 (+) Length   312 a.a.
NCBI ID   WP_002993471.1    Uniprot ID   -
Organism   Streptococcus pyogenes Alab49     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 97160..108098
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS00640 (SPYALAB49_000125) rpoC 97927..101550 (+) 3624 WP_011527438.1 DNA-directed RNA polymerase subunit beta' -
  SPYALAB49_RS00645 (SPYALAB49_000126) - 101702..102067 (+) 366 WP_002986560.1 DUF1033 family protein -
  SPYALAB49_RS00650 (SPYALAB49_000127) comYA 102160..103098 (+) 939 WP_002993471.1 competence type IV pilus ATPase ComGA Machinery gene
  SPYALAB49_RS00655 (SPYALAB49_000128) comYB 103034..104068 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  SPYALAB49_RS00660 (SPYALAB49_000129) comYC 104070..104396 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  SPYALAB49_RS00665 (SPYALAB49_000130) comGD 104371..104799 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  SPYALAB49_RS00670 (SPYALAB49_000131) comGE 104756..105040 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  SPYALAB49_RS00675 (SPYALAB49_000132) comYF 105033..105467 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  SPYALAB49_RS00680 (SPYALAB49_000133) comGG 105451..105777 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  SPYALAB49_RS00685 (SPYALAB49_000134) comYH 105875..106828 (+) 954 WP_010921802.1 class I SAM-dependent methyltransferase Machinery gene
  SPYALAB49_RS00690 (SPYALAB49_000135) - 106888..108084 (+) 1197 WP_010921803.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35032.27 Da        Isoelectric Point: 8.5799

>NTDB_id=49508 SPYALAB49_RS00650 WP_002993471.1 102160..103098(+) (comYA) [Streptococcus pyogenes Alab49]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=49508 SPYALAB49_RS00650 WP_002993471.1 102160..103098(+) (comYA) [Streptococcus pyogenes Alab49]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAGTTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.736

99.679

0.615
  comYA Streptococcus mutans UA140

61.736

99.679

0.615
  comYA Streptococcus gordonii str. Challis substr. CH1

60.772

99.679

0.606
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.645

99.359

0.603
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.807

99.679

0.596
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae D39

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae R6

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

59.164

99.679

0.59
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369

Multiple sequence alignment