Detailed information NTG0049283

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPNOXC_RS10945
• Genome accession: NC_017592
• Coordinates: 2031678..2032430 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae OXC141
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2026678..2037430

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNOXC_RS13375	-	2029113..2030787 (-)	1675	Protein_2056	YhgE/Pip domain-containing protein	-
SPNOXC_RS10930 (SPNOXC19760)	-	2030894..2031436 (+)	543	WP_001158255.1	TetR/AcrR family transcriptional regulator	-
SPNOXC_RS10945 (SPNOXC19770)	comE	2031678..2032430 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPNOXC_RS10950 (SPNOXC19780)	comD/comD1	2032427..2033752 (-)	1326	WP_014632435.1	competence system sensor histidine kinase ComD	Regulator
SPNOXC_RS10955 (SPNOXC19790)	comC/comC1	2033773..2033898 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPNOXC_RS10965 (SPNOXC19800)	rlmH	2034181..2034660 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPNOXC_RS10970 (SPNOXC19810)	htrA	2034843..2036024 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
SPNOXC_RS10975 (SPNOXC19820)	spo0J	2036082..2036840 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=49283 SPNOXC_RS10945 WP_000866065.1 2031678..2032430(-) (comE) [Streptococcus pneumoniae OXC141]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=49283 SPNOXC_RS10945 WP_000866065.1 2031678..2032430(-) (comE) [Streptococcus pneumoniae OXC141]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408