Detailed information NTG0049207

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: INV104_RS11330
• Genome accession: NC_017591
• Coordinates: 2136945..2137697 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae INV104
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2131945..2142697

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
INV104_RS12570	-	2132958..2134305 (-)	1348	Protein_2138	IS3 family transposase	-
INV104_RS14170	-	2134378..2135981 (-)	1604	Protein_2139	YhgE/Pip family protein	-
INV104_RS11315 (INV104_19360)	-	2136160..2136702 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
INV104_RS11330 (INV104_19370)	comE	2136945..2137697 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
INV104_RS11335 (INV104_19380)	comD	2137694..2139008 (-)	1315	Protein_2142	competence system sensor histidine kinase ComD	-
INV104_RS11340 (INV104_19390)	comC/comC2	2139029..2139154 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
INV104_RS11350 (INV104_19400)	rlmH	2139436..2139915 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
INV104_RS11355 (INV104_19410)	htrA	2140098..2141279 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
INV104_RS11360 (INV104_19420)	spo0J	2141337..2142095 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=49207 INV104_RS11330 WP_000866065.1 2136945..2137697(-) (comE) [Streptococcus pneumoniae INV104]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=49207 INV104_RS11330 WP_000866065.1 2136945..2137697(-) (comE) [Streptococcus pneumoniae INV104]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408